6-amino-2-hydroxy-2H-acenaphthylen-1-one | 944726-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-amino-2-hydroxy-2H-acenaphthylen-1-one
• CAS: 944726-99-2
• 化学式: C₁₂H₉NO₂
• 分子量: 199.209
• InChiKey: SJHOZPYHVZIGPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-aminoacenaphthene quinone 在 蔗糖 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 48.0h， 生成 6-amino-2-hydroxy-2H-acenaphthylen-1-one
  参考文献：
  名称：

  Preparation of chiral trans-5-substituted-acenaphthene-1,2-diols by baker’s yeast-mediated reduction of 5-substituted-acenaphthylene-1,2-diones

  摘要：

  A series of trans-5-substauted-acenaphthene-1,2-diols were obtained in 21-72% yield with 97-100% ee by baker's yeast-mediated reduction of the corresponding acenaphthylene-1,2-diones, in the presence of DMSO as a co-solvent and under vigorous agitation The absolute configuration of (-)-trans-5-methoxy-acenaphthene-1,2-diol trans-3b and (-)-trans-5-bromo-acenaphthene-12-diol trans-3c was assigned as (S,S) and (-)-trans-5-thiomorpholin-acenaphthene-1,2-diol trans-3d was established as (R,R) by exciton-coupled circular dichroism. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetasy.2010.04.048