N-[4-[(3,5-Dimethylphenyl)(iso-propyl)amino]-1-methylpyrrole-2-carbonyl]pyrrolidine | 1058178-10-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-[4-[(3,5-Dimethylphenyl)(iso-propyl)amino]-1-methylpyrrole-2-carbonyl]pyrrolidine
• 英文别名: [4-(3,5-dimethyl-N-propan-2-ylanilino)-1-methylpyrrol-2-yl]-pyrrolidin-1-ylmethanone
• CAS: 1058178-10-1
• 化学式: C₂₁H₂₉N₃O
• 分子量: 339.481
• InChiKey: QCVKIPBEESFZDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4-(3,5-dimethylphenylamino)-1-methyl-1H-pyrrol-2-yl)(pyrrolidin-1-yl)methanone 、 2-碘代丙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 以13%的产率得到N-[4-[(3,5-Dimethylphenyl)(iso-propyl)amino]-1-methylpyrrole-2-carbonyl]pyrrolidine
  参考文献：
  名称：

  4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor

  摘要：

  Various 4-(anilino)pyrrole-2-carboxamides were designed and synthesized as novel androgen receptor (AR) antagonists without steroidal or anilide structure, based on our strategy for developing full antagonists of nuclear receptors. Introduction of a bulky N-alkyl group, such as a cyclohexylmethyl or benzyl group, increased the binding affinity for wild-type AR and the potency for growth inhibition of androgen-dependent SC-3 cells. Among the compounds obtained, N-[4-[(benzyl)(4-nitrophenyl)amino]-1-methylpyrrole-2-carbonyl]pyrrolidine (22) is as potent an AR antagonist as the typical anilide-type AR antagonists hydroxyflutamide and bicalutamide. Further, compound 22 had potent binding affinity for T877A mutated AR, and dose-dependently inhibited the testosterone-induced production of prostate-specific antigen in LNCaP cells bearing T877A AR. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.063

文献信息

• 4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor
  作者：Ken-ichi Wakabayashi、Keisuke Imai、Hiroyuki Miyachi、Yuichi Hashimoto、Aya Tanatani

  DOI：10.1016/j.bmc.2008.05.063

  日期：2008.7

  Various 4-(anilino)pyrrole-2-carboxamides were designed and synthesized as novel androgen receptor (AR) antagonists without steroidal or anilide structure, based on our strategy for developing full antagonists of nuclear receptors. Introduction of a bulky N-alkyl group, such as a cyclohexylmethyl or benzyl group, increased the binding affinity for wild-type AR and the potency for growth inhibition of androgen-dependent SC-3 cells. Among the compounds obtained, N-[4-[(benzyl)(4-nitrophenyl)amino]-1-methylpyrrole-2-carbonyl]pyrrolidine (22) is as potent an AR antagonist as the typical anilide-type AR antagonists hydroxyflutamide and bicalutamide. Further, compound 22 had potent binding affinity for T877A mutated AR, and dose-dependently inhibited the testosterone-induced production of prostate-specific antigen in LNCaP cells bearing T877A AR. (c) 2008 Elsevier Ltd. All rights reserved.