tert-butyl (3S,5S,6R)-3-(3-hydroxy(113C)propyl)-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate | 1196980-35-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: tert-butyl (3S,5S,6R)-3-(3-hydroxy(113C)propyl)-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate
• CAS: 1196980-35-4
• 化学式: C₂₄H₂₉NO₅
• 分子量: 413.476
• InChiKey: GLSPRBRMHFIAFI-NNIUAPRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl (3S,5S,6R)-3-(3-hydroxy(113C)propyl)-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate 、 对甲苯磺酰氯 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 27.0h， 以67%的产率得到tert-butyl (3S,5S,6R)-3-[3-(4-methylphenyl)sulfonyloxy(113C)propyl]-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate
  参考文献：
  名称：

  Enantioselective Syntheses of α-Fmoc-Pbf-[2-¹³C]-l-arginine and Fmoc-[1,3-¹³C₂]-l-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT₈₋₁₃

  摘要：

  Enantioselective syntheses of selectively labeled, orthogonally protected [2-C-13]L-arginine and [1,3-C-13(2)]-L-proline are described from the commercially available precursors [2-C-13]bromoacetic acid and potassium [C-13]cyanide, Interestingly the enhanced signal assigned to C-2 in the C-13 NMR spectrum of alpha-Fmoc-Pbf-[2-C-13]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-C-13]-Arg9 and [1,3-C-13(2)]-Pro 10 labeled ligand (NT8-13) by manual Fmoc-SPSS.

  DOI：

  10.1021/jo9014497
• 作为产物：
  描述：

  tert-butyl (3S,5S,6R)-3-[3-[tert-butyl(dimethyl)silyl]oxy(113C)propyl]-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 144.0h， 以57%的产率得到tert-butyl (3S,5S,6R)-3-(3-hydroxy(113C)propyl)-2-oxo-5,6-diphenyl-(213C)1,4-oxazinane-4-carboxylate
  参考文献：
  名称：

  Enantioselective Syntheses of α-Fmoc-Pbf-[2-¹³C]-l-arginine and Fmoc-[1,3-¹³C₂]-l-proline and Incorporation into the Neurotensin Receptor 1 Ligand, NT₈₋₁₃

  摘要：

  Enantioselective syntheses of selectively labeled, orthogonally protected [2-C-13]L-arginine and [1,3-C-13(2)]-L-proline are described from the commercially available precursors [2-C-13]bromoacetic acid and potassium [C-13]cyanide, Interestingly the enhanced signal assigned to C-2 in the C-13 NMR spectrum of alpha-Fmoc-Pbf-[2-C-13]-L-arginine was very broad at room temperature. The two Fmoc-labeled amino acids were used to prepare [2-C-13]-Arg9 and [1,3-C-13(2)]-Pro 10 labeled ligand (NT8-13) by manual Fmoc-SPSS.

  DOI：

  10.1021/jo9014497