(3,5-dimethoxy-phenyl)-(1,2-dimethyl-1H-benzoimidazol-5-yl)-methanone | 878495-93-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3,5-dimethoxy-phenyl)-(1,2-dimethyl-1H-benzoimidazol-5-yl)-methanone
• 英文别名: (3,5-dimethoxyphenyl)-(1,2-dimethylbenzimidazol-5-yl)methanone
• CAS: 878495-93-3
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: FFDWYHJIGMHYTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  53.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3,5-dimethoxy-phenyl)-(1,2-dimethyl-1H-benzoimidazol-5-yl)-methanol 在 二氧化锰 作用下， 以 二氯甲烷 为溶剂， 反应 17.0h， 以to afford (3,5-dimethoxy-phenyl)-(1,2-dimethyl-1H-benzoimidazol-5-yl)-methanone (2.0 g, 99%) as an off white solid的产率得到(3,5-dimethoxy-phenyl)-(1,2-dimethyl-1H-benzoimidazol-5-yl)-methanone
  参考文献：
  名称：

  SUBSTITUTED HETEROCYCLIC COMPOUNDS AND USES THEREOF

  摘要：

  本发明涉及替代杂环化合物及包含替代杂环化合物的组合物。本发明还涉及通过向需要的受试者中给予一种或多种替代杂环化合物来预防或治疗各种疾病和障碍的方法。特别地，本发明涉及通过向需要的受试者中给予一种或多种替代杂环化合物来预防或治疗癌症或炎症性疾病的方法。本发明还涉及包含一种或多种替代杂环化合物的制品和套件。

  公开号：

  US20090042875A1

文献信息

• Substituted heterocyclic compounds and uses thereof
  申请人：Muller W. George

  公开号：US20060052596A1

  公开（公告）日：2006-03-09

  The present invention relates to substituted heterocyclic compounds and compositions comprising a substituted heterocyclic compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more substituted heterocyclic compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more substituted heterocyclic compounds. The present invention further relates to articles of manufacture and kits comprising one or more substituted heterocyclic compounds.

  本发明涉及取代杂环化合物和包含取代杂环化合物的组合物。本发明还涉及通过向需要的受试者施用一种或多种取代杂环化合物来预防或治疗各种疾病和紊乱的方法。具体来说，本发明涉及通过向需要的受试者施用一种或多种取代杂环化合物来预防或治疗癌症或炎症性紊乱的方法。本发明还涉及包含一种或多种取代杂环化合物的制品和试剂盒。
• US7468446B2
  申请人：——

  公开号：US7468446B2

  公开（公告）日：2008-12-23
• [EN] SUBSTITUTED HETEROCYCLIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES HETEROCYCLIQUES SUBSTITUES ET LEURS UTILISATIONS
  申请人：CELGENE CORP

  公开号：WO2006028963A2

  公开（公告）日：2006-03-16

  The present invention relates to substituted heterocyclic compounds and compositions comprising a substituted heterocyclic compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more substituted heterocyclic compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more substituted heterocyclic compounds. The present invention further relates to articles of manufacture and kits comprising one or more substituted heterocyclic compounds.