benzoic acid-(5α-ergostanyl-(3β)-ester) | 6424-44-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: benzoic acid-(5α-ergostanyl-(3β)-ester)
• 英文别名: Benzoesaeure-(5α-ergostanyl-(3β)-ester)；3β-benzoyloxy-5a-ergostane；Ergostanol benzoate；[(3S,5S,8R,9S,10S,13R,14S,17R)-17-[(2R,5S)-5,6-dimethylheptan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] benzoate
• CAS: 6424-44-8
• 化学式: C₃₅H₅₄O₂
• 分子量: 506.813
• InChiKey: QSHAZQWPTYSPBQ-GFKVJPSPSA-N

物化性质

• 沸点：
  564.480±19.00 °C(Press: 760.00 Torr)(predicted)
• 密度：
  1.022±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  11.8
• 重原子数：
  37
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzoic acid-(5α-ergostanyl-(3β)-ester) 、 臭氧 、 吡啶 在 Acetone cardice 、 臭氧 、 氩 、 二甲基硫 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以leaving 3.90 g of tan fluff的产率得到5alpha-Pregnane-20-carboxaldehyde
  参考文献：
  名称：

  Antihypercholesterolemic compounds and related pharmaceutical

  摘要：

  提供了新型抗高胆固醇药物。其中一组化合物的结构式(I)如下：##STR1## 其中R是C-17侧链，R.sup.1是--OH，.dbd.O或类似物，X和Y是N，N.fwdarw.O，CH，C--OH，C--OCH.sub.3或C--Z。提供了使用式(I)化合物或其他新型氧化固醇类似物治疗高胆固醇血症的方法，以及含有这些化合物的制药组合物。

  公开号：

  US05510340A1
• 作为产物：
  描述：

  (3beta,5alpha)-麦角甾烷-3-醇 、 苯甲酰氯 在 吡啶 作用下， 生成 benzoic acid-(5α-ergostanyl-(3β)-ester)
  参考文献：
  名称：

  271.分子旋转差异法在类固醇上的应用。第五部分。7：8位的烯烃不饱和

  摘要：

  DOI：

  10.1039/jr9480001354

文献信息

• The Role of Radial Clearance on the Performance of Foil Air Bearings
  作者：Kevin Radil、Samuel Howard、Brian Dykas

  DOI：10.1080/10402000208982578

  日期：2002.1

  Load capacity tests were conducted to determine how radial clearance variations affect the load capacity coefficient of foil air bearings. Two Generation III foil air bearings with the same design but possessing different initial radial clearances were tested at room temperature against an as-ground PS304 coated journal operating at 30000 rpm. Increases in radial clearance were accomplished by reducing the journal's outside diameter via an in-place grinding system. Front each load capacity test the bearing load capacity coefficient was calculated from the rule-of-thumb (ROT) model developed for foil air bearings.The test results indicate that, in terms of the load capacity coefficient, radial clearance has a direct impact on the performance of the foil air bearing. Each test bearing exhibited an optimum radial clearance that resulted in a maximum load capacity coefficient. Relative to this optimum value are two separate operating regimes that are governed by different modes of failure. Bearings operating with radial clearances less than the optimum exhibit load capacity coefficients that are a strong function of radial clearance and are prone to a thermal runaway failure mechanism and bearing seizure. Conversely, a bearing operating with a radial clearance m,ice the optimum suffered only a 20% decline in its maximum load capacity coefficient and did not experience any thermal management problems. However, it is unknown to what degree these changes in radial clearance had on other performance parameters, such (is the stiffness and damping properties of the bearings.
• US5510340A
  申请人：——

  公开号：US5510340A

  公开（公告）日：1996-04-23
• US5688780A
  申请人：——

  公开号：US5688780A

  公开（公告）日：1997-11-18