(13S,16S)-16-{4-[(R)-5-((R)-2-tert-butoxycarbonylamino-propionyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-1-cyclopropyl-7-fluoro-16-hydroxy-4-oxo-1,4,13,15,16,17-hexahydro-12H-11-oxa-1,14-diaza-cyclopenta[a]phenanthrene-3-carboxylic acid benzyl ester 在
palladium 10% on activated carbon
氢气 作用下,
以
1,4-二氧六环 、
甲醇 为溶剂,
反应 6.0h,
以72%的产率得到(13S,16S)-16-{4-[(R)-5-((R)-2-tert-butoxycarbonylamino-propionyloxymethyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenoxymethyl}-1-cyclopropyl-7-fluoro-16-hydroxy-4-oxo-1,4, 13,15,16,17-hexahydro-12H-11-oxa-1,14-diaza-cyclopenta[a]phenanthrene-3-carboxylic acid