(2-(二氟甲氧基)吡啶-4-基)甲胺 | 943894-77-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (2-(二氟甲氧基)吡啶-4-基)甲胺
• 英文名称: (2-(difluoromethoxy)pyridin-4-yl)methanamine
• 英文别名: [2-(difluoromethoxy)pyridin-4-yl]methanamine
• CAS: 943894-77-7
• 化学式: C₇H₈F₂N₂O
• mdl: MFCD18261339
• 分子量: 174.15
• InChiKey: LNUNPTNLRWDQQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.285
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2-(二氟甲氧基)吡啶-4-基)甲胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 49.0h， 生成 1-[[2-(difluoromethoxy)pyridin-4-yl]methyl]-3-spiro[2.3]hexan-5-ylurea
  参考文献：
  名称：

  WO2023/91461

  摘要：

  公开号：

文献信息

• Heterobicyclic metalloprotease inhibitors
  申请人：Steeneck Christoph

  公开号：US20070155738A1

  公开（公告）日：2007-07-05

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• Heterobicyclic Metalloprotease Inhibitors
  申请人：STEENECK Christoph

  公开号：US20090312312A1

  公开（公告）日：2009-12-17

  The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting and MMP-3 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 and MMP-3 inhibitors.
• US7795245B2
  申请人：——

  公开号：US7795245B2

  公开（公告）日：2010-09-14
• NOVEL HETEROARYL-UREA COMPOUNDS AS KV7.2 INHIBITORS
  申请人：[en]ICAGEN, LLC

  公开号：WO2023091554A1

  公开（公告）日：2023-05-25

  The invention provides new heteroaromatic compounds having the general formula (I'), or a solvate or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, Y1, Y2, Y3, and n are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
• WO2023/121992
  申请人：——

  公开号：——

  公开（公告）日：——