24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside | 78213-32-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside
• 英文别名: 24-O-acetylhydroshengmanol 3-O-β-D-xyloside；24-epi-24-O-acetylhydroshengmanol-3-O-β-D-xylopyranoside；24-O-acetylhydroshengmanol 3-β-D-xylopyranoside；[(1S)-1-[(1S,4R,5R,6R,8R,10R,11R,12S,13R,16R,18S,21R)-10,11-dihydroxy-4,6,12,17,17-pentamethyl-18-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-oxahexacyclo[11.9.0.01,21.04,12.05,10.016,21]docosan-8-yl]-2-hydroxy-2-methylpropyl] acetate
• CAS: 78213-32-8
• 化学式: C₃₇H₆₀O₁₁
• 分子量: 680.877
• InChiKey: PJGMIZSCETWMLA-USIWENNYSA-N

物化性质

• 熔点：
  235-237 °C
• 沸点：
  787.5±60.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  48
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  175
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  24-O-acetylhydroshengmanol 3-O-β-D-xylopyranoside 在 溶剂黄146 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 反应 3.5h， 生成 24-O-acetylhydroshengmanol 3-[beta]-D-xylopyranoside(delta16,17)-enol ether
  参考文献：
  名称：

  WO2008/136863

  摘要：

  公开号：

文献信息

• SYNTHESIS OF COMPOUNDS USEFUL AS MODULATORS OF AMYLOID-BETA PRODUCTION
  申请人：Satori Pharmaceuticals, Inc.

  公开号：EP2073638B1

  公开（公告）日：2013-05-15
• Compounds useful for treating neurodegenerative disorders
  申请人：Findeis A. Mark

  公开号：US20070010503A1

  公开（公告）日：2007-01-11

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• COMPOUNDS USEFUL FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：FINDEIS Mark A.

  公开号：US20100144689A1

  公开（公告）日：2010-06-10

  As described herein, the present invention provides compounds useful for treating or lessening the severity of a neurodegenerative disorder. The present invention also provides methods of treating or lessening the severity of such disorders wherein said method comprises administering to a patient a compound of the present invention, or composition thereof. Said method is useful for treating or lessening the severity of, for example, Alzheimer's disease.
• US7851641B2
  申请人：——

  公开号：US7851641B2

  公开（公告）日：2010-12-14
• US8263755B2
  申请人：——

  公开号：US8263755B2

  公开（公告）日：2012-09-11