cis-2,3-dimethyltetrahydropyran | 81554-06-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: cis-2,3-dimethyltetrahydropyran
• 英文别名: (2S,3S)-2,3-dimethyloxane
• CAS: 81554-06-5
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: CNOREWPIWZJDQN-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-methyl-1,5-hexanediol 在 吡啶 作用下， 生成 trans-2,3-dimethyltetrahydropyran 、 cis-2,3-dimethyltetrahydropyran
  参考文献：
  名称：

  Conformational analysis. 42. Monosubstituted tetrahydropyrans

  摘要：

  DOI：

  10.1021/ja00377a015

文献信息

• LACTAM CONTAINING CYCLIC DIAMINES AND DERIVATIVES AS FACTOR XA INHIBITORS
  申请人：Qiao X Jennifer

  公开号：US20070135428A1

  公开（公告）日：2007-06-14

  The present application describes lactam-containing cyclic diamines and derivatives thereof of Formula I: P 4 -M-M 4 I or pharmaceutically acceptable salt forms thereof, wherein M is a non-aromatic carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

  本申请描述了公式I：P4-M-M4I或其药学上可接受的盐形式的含有内酰胺的环状二胺及其衍生物，其中M为非芳香族碳环或杂环。本发明的化合物可用作胰蛋白酶样丝氨酸蛋白酶的抑制剂，特别是Xa因子的抑制剂。
• C5-C6 OXACYCLIC-FUSED THIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS, AND THEIR USE
  申请人：Cumming Jared N.

  公开号：US20140023668A1

  公开（公告）日：2014-01-23

  In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula: (I) and tautomers and stereoisomers thereof, and pharmaceutically acceptable salts of said compounds, said tautomeros and said stereoisomers, wherein each of ring A, ring B, ring C, R 2 , R 3 , R 4 , m, n, p, and -L 1 - is as defined herein. The novel compounds of the invention may be useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including Alzheimer's disease, are also disclosed.
• US7205318B2
  申请人：——

  公开号：US7205318B2

  公开（公告）日：2007-04-17
• US9221839B2
  申请人：——

  公开号：US9221839B2

  公开（公告）日：2015-12-29