1-cyclopentyl-3-(3-methanesulfonyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione | 1174227-84-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 1-cyclopentyl-3-(3-methanesulfonyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione
• 英文别名: 1-Cyclopentyl-7-methoxy-3-(3-methylsulfonylphenyl)pyrimido[5,4-c]quinoline-2,4-dione
• CAS: 1174227-84-9
• 化学式: C₂₄H₂₃N₃O₅S
• 分子量: 465.53
• InChiKey: LTRCCXKUSQMIAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  105
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-cyclopentyl-7-methoxy-3-(3-methylsulfanyl-phenyl)-1H-pyrimido[5,4-c]quinoline-2,4-dione 在 过氧乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 1-cyclopentyl-3-(3-methanesulfonyl-phenyl)-7-methoxy-1H-pyrimido[5,4-c]quinoline-2,4-dione
  参考文献：
  名称：

  [EN] TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-a SYNTHESIS AND AS PDE4 INHIBITORS
  [FR] COMPOSÉS TRICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE LA SYNTHÈSE DE TNF-? ET EN TANT QU'INHIBITEURS DE PDE4

  摘要：

  本发明涉及化合物的化学式（I），如本文所定义，药物组合物以及在治疗由TNF-alpha或PDE4介导的疾病或疾病中的使用方法，包括但不限于类风湿关节炎。

  公开号：

  WO2009094528A1

文献信息

• Tricyclic Compounds As Modulators of TNF-alpha Synthesis
  申请人：Mjalli Adnan M. M.

  公开号：US20100190808A1

  公开（公告）日：2010-07-29

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及公式(I)所定义的化合物、药物组合物以及在治疗由TNF-alpha或PDE4介导的疾病或疾病中使用的方法，包括但不限于类风湿关节炎。
• Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors
  申请人：Mjalli Adnan M.M.

  公开号：US20110160234A1

  公开（公告）日：2011-06-30

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及化学式（I）所定义的化合物，制药组合物以及在治疗由TNF-α或PDE4介导的疾病或疾病中使用的方法，包括但不限于类风湿性关节炎。
• TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS
  申请人：vTv Therapeutics LLC

  公开号：US20150374700A1

  公开（公告）日：2015-12-31

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及公式（I）所定义的化合物、制药组合物及其在治疗由TNF-α或PDE4介导的疾病或症状方面的使用方法，包括但不限于类风湿性关节炎。
• Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
  申请人：vTv Therapeutics LLC

  公开号：US10085990B2

  公开（公告）日：2018-10-02

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to ulcerative colitis and Crohn's disease.

  本发明涉及如本文所定义的式 (I) 化合物、药物组合物以及用于治疗由 TNF-α 或 PDE4 介导的病症或紊乱（包括但不限于溃疡性结肠炎和克罗恩病）的方法。
• Tricyclic compounds as modulators of TNF-alpha synthesis and as PDE4 inhibitors
  申请人：vTv Therapeutics LLC

  公开号：US10391097B2

  公开（公告）日：2019-08-27

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to ulcerative colitis and Crohn's disease.

  本发明涉及如本文所定义的式 (I) 化合物、药物组合物以及用于治疗由 TNF-α 或 PDE4 介导的病症或紊乱（包括但不限于溃疡性结肠炎和克罗恩病）的方法。