3,7-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-5-one | 1005498-36-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 3,7-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-5-one
• 英文别名: 3,7-dimethyl-6,7,8,9-tetrahydropyrido[2,3-b]indol-5-one
• CAS: 1005498-36-1
• 化学式: C₁₃H₁₄N₂O
• 分子量: 214.267
• InChiKey: NWRPVJLSSUCJRP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  45.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3,7-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-5-one 在 pyridinium hydrobromide perbromide 作用下， 以 乙腈 为溶剂， 反应 72.0h， 生成
  参考文献：
  名称：

  WO2008/16184

  摘要：

  公开号：
• 作为产物：
  描述：

  3-[(3-溴-5-甲基吡啶-2-基)氨基]-5-甲基环己-2-烯-1-酮 在 bis-triphenylphosphine-palladium(II) chloride caesium carbonate 作用下， 以 甲苯 为溶剂， 反应 8.0h， 以83%的产率得到3,7-dimethyl-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indol-5-one
  参考文献：
  名称：

  WO2008/16184

  摘要：

  公开号：

文献信息

• ALPHA-CARBOLINE DERIVATIVES AND METHODS FOR PREPARATION THEREOF
  申请人：Mizuno Masahiro

  公开号：US20090326229A1

  公开（公告）日：2009-12-31

  To provide methods for preparing alpha-carboline derivatives in few steps, as well as conveniently and industrially advantageously. A method for preparation of a compound represented by Formula (II) or a salt thereof, comprising subjecting a compound represented by Formula (I) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base; a method for preparation of a compound represented by Formula (IX) or a salt thereof, comprising subjecting a compound represented by Formula (VII) or a salt thereof to a ring closure reaction in the presence of a palladium catalyst, a ligand, and a base, and subsequently to an aromatization reaction; and methods for preparation of compounds represented by Formulae (XV), (XVII), and (XIX) or a salt thereof, comprising subjecting respective compounds represented by Formulae (II) and (IX) or a salt thereof to a reaction for introducing a leaving group when necessary, and subsequently to a coupling reaction: wherein the symbols respectively represent the same meaning as defined in the present specification.

  提供几步制备α-咔啉衍生物的方法，以及方便和具有工业优势的方法。一种制备式（II）化合物或其盐的方法，包括在钯催化剂、配体和碱的存在下，将式（I）化合物或其盐进行环闭合反应；一种制备式（IX）化合物或其盐的方法，包括在钯催化剂、配体和碱的存在下，将式（VII）化合物或其盐进行环闭合反应，然后进行芳构化反应；以及制备式（XV）、（XVII）和（XIX）化合物或其盐的方法，包括在必要时将式（II）和（IX）化合物或其盐分别进行引入离去基团的反应，然后进行偶联反应：其中符号分别表示本说明书中定义的相同含义。
• Oxygen scavenger compositions
  申请人：Cryovac, Inc.

  公开号：EP1050556A1

  公开（公告）日：2000-11-08

  A composition suitable for scavenging oxygen is disclosed which comprises a carrier having a combination of a hydroxosulfitometalate and a transition metal ion source.

  本发明公开了一种适用于清除氧气的组合物，该组合物包括一种具有羟基硫代甲酸酯和过渡金属离子源组合的载体。
• Oxygen scavenging system and compositions
  申请人：Cryovac, Inc.

  公开号：EP1050555A1

  公开（公告）日：2000-11-08

  An oxygen scavenging system and composition capable of providing good oxygen absorption activity and capabilities, wherein the system comprises a modified anionic hydrotalcite particulate material and a transition metal ion source.

  一种能够提供良好氧吸收活性和能力的氧清除系统和组合物，其中该系统包括改性阴离子水滑石颗粒材料和过渡金属离子源。
• Composition for treating cells and method for qualitatively and quantitatively customizing the formulation thereof
  申请人：——

  公开号：US20030073580A1

  公开（公告）日：2003-04-17

  The instant invention relates to a composition of solution stable Ca ++ , Mg ++ , N 3− , and S 6+ moieties and a method of varying the quantitative proportions of at least the solution stable Ca ++ and Mg ++ moieties in the composition. In its more complex expression, the invention provides a composition that includes compensating proportions of substantially any of the essential micronutrients or macronutrients in a solution stable form. In a first preferred embodiment, the invention has utility as a soil treatment composition. In a second preferred embodiment, the invention has utility as a cell culture medium. The invention further contemplates the recovery of a substantially pure CO 2 product formed by the reaction process that produces the instant composition.

  本发明涉及一种溶液稳定的 Ca +&plus； 、镁 +&plus； , N 3- 和 S 6&plus； 基团的方法，以及至少改变溶液中稳定 Ca 和镁 和镁 和 Mg 分子在组合物中的数量比例。在更复杂的表述中，本发明提供了一种组合物，该组合物包括基本上任何一种溶液稳定形式的必需微量营养素或宏量营养素的补偿比例。在第一个优选实施方案中，本发明可用作土壤处理组合物。在第二个优选实施方案中，本发明可用作细胞培养基。本发明还考虑回收基本纯净的 CO 2 产品。
• COMPOSITION FOR TREATING CELLS AND METHODS FOR QUALITATIVELY AND QUANTITATIVELY CUSTOMIZING THE FORMULATION THEREOF FOR A HEURISTICALLY DERIVED LIVING CELL NUTRIENT-COMPOSITION-ON-DEMAND
  申请人：Runkis, Walter H.

  公开号：EP1412284A2

  公开（公告）日：2004-04-28