布托巴胺盐酸盐 | 74432-68-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 布托巴胺盐酸盐
• 英文名称: (R,R)-Ractopamine hydrochloride
• 英文别名: Butopamine Hydrochloride；4-[(3R)-3-[[(2R)-2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]butyl]phenol;hydrochloride
• CAS: 74432-68-1
• 化学式: C₁₈H₂₃NO₃*ClH
• 分子量: 337.846
• InChiKey: JHGSLSLUFMZUMK-WJKBNZMCSA-N

物化性质

• 熔点：
  176-176.5° (dec)
• 比旋光度：
  D -22.7°; 365 -71.2° (c = 3.7 mg/ml in methanol)

计算性质

• 辛醇/水分配系数(LogP)：
  3.16
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.7
• 氢给体数：
  5
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ractopamine 在 盐酸 作用下， 以 水 为溶剂， 生成 布托巴胺盐酸盐 、 SR-ractopamine hydrochloride
  参考文献：
  名称：

  Use of RR/SR-ractopamine

  摘要：

  本发明公开了一种通过向动物投与RR-拉托巴胺和SR-拉托巴胺混合物的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法。同时，还公开了制造RR/SR-拉托巴胺的方法。

  公开号：

  US20090143480A1

文献信息

• Methods of Accelerating Muscle Growth, Decreasing Fat Deposits and Improving Feed Efficiency in Livestock Animals
  申请人：Aberg A.K. Gunnar

  公开号：US20070282010A1

  公开（公告）日：2007-12-06

  A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed

  本发明揭示了一种通过向动物投与纯或基本纯的RR-异构体的拉克托巴胺的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法。还揭示了能够增加动物瘦肉沉积或减少体脂肪，或促进或改善动物生长或改善动物饲料效率的动物饲料制剂和组合物以及制药制剂。揭示了包括治疗有效量的纯或基本纯的RR-异构体的拉克托巴胺的动物饲料制剂、组合物和制药制剂。
• USE OF RACTOPAMINE ENANTIOMERS
  申请人：London Calvin

  公开号：US20080070990A1

  公开（公告）日：2008-03-20

  A method of promoting or improving the feed efficiency and the muscle to fat ratio livestock animal by administering to the animal a therapeutically effective amount of a pure or substantially pure RR-enantiomer of ractopamine. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or for improving lean meat to fat ratio in an animal or for promoting or improving the growth of an animal or for improving the feed efficiency of an animal, the feed preparation, compositions and pharmaceutical preparations including a therapeutically effective amount of a pure or substantially pure RR-enantiomer of ractopamine.

  通过给动物施加纯的或几乎纯的RR-对映异构体的治疗有效量，促进或改善饲料效率和肌肉到脂肪比例的畜禽动物的方法。还披露了动物饲料制剂和组成物以及制剂，能够增加动物的瘦肉沉积或改善动物的瘦肉到脂肪比例或促进或改善动物的生长或改善动物的饲料效率，饲料制剂，组成物和制剂包括纯的或几乎纯的RR-对映异构体的治疗有效量。
• Use Of RR/SR-Ractopamine
  申请人：Aberg A.K. Gunnar

  公开号：US20100184865A1

  公开（公告）日：2010-07-22

  A method of promoting weight loss in animals or humans by administering thereto a therapeutically effective amount of a mixture of RR-ractopamine and SR-ractopamine is disclosed.

  本发明揭示了一种通过向动物或人类施用RR-拉克托帕明和SR-拉克托帕明混合物的治疗有效剂量来促进减重的方法。
• METHOD OF ACCELERATING MUSCLE GROWTH, DECREASING FAT DEPOSITS AND IMPROVING FEED EFFICIENCY IN LIVESTOCK ANIMALS
  申请人：Aberg A.K. Gunnar

  公开号：US20120065271A1

  公开（公告）日：2012-03-15

  A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed

  本发明公开了一种通过向动物投与纯或几乎纯的RR-异构体拉克托巴胺的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比率的方法。还公开了能够增加动物瘦肉沉积或减少体脂肪，或促进或改善动物生长或改善动物饲料效率的动物饲料制剂和组合物以及药物制剂。公开了包括治疗有效量的纯或几乎纯的RR-异构体拉克托巴胺的饲料制剂、组合物和药物制剂。
• METHODS OF ACCELERATING MUSCLE GROWTH, DECREASING FAT DEPOSITS AND IMPROVING FEED EFFICIENCY IN LIVESTOCK ANIMALS
  申请人：BRIDGE PHARMA, INC.

  公开号：US20130090295A1

  公开（公告）日：2013-04-11

  A method of promoting or improving the feed efficiency and the muscle to fat ratio in animals by administering to the animals a therapeutically effective amount of a pure or substantially pure RR-isomer of ractopamine is disclosed. Also disclosed are animal feed preparations and compositions and pharmaceutical preparations capable of increasing lean meat deposition in an animal or decreasing body fat, or promoting or improving the growth of an animal or improving the feed efficiency of an animal. Feed preparation, compositions and pharmaceutical preparations including therapeutically effective amounts of a pure or substantially pure RR-isomer of ractopamine are disclosed.

  本发明公开了一种通过向动物投与纯或基本纯的RR异构体雷克多巴胺的治疗有效量来促进或改善动物的饲料效率和肌肉脂肪比的方法。本发明还公开了动物饲料制剂和组成物，以及能够增加动物的瘦肉沉积或减少体脂肪，或促进或改善动物生长或提高动物饲料效率的制药制剂。公开了包括纯或基本纯的RR异构体雷克多巴胺的治疗有效量的饲料制剂、组成物和制药制剂。