5-bromo-7-methoxyisoquinoline | 1824478-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 5-bromo-7-methoxyisoquinoline
• CAS: 1824478-07-0
• 化学式: C₁₀H₈BrNO
• 分子量: 238.084
• InChiKey: FBXSAFYZRCURIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  zinc(II) cyanide 、 5-bromo-7-methoxyisoquinoline 在 四(三苯基膦)钯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以67 %的产率得到7-methoxyisoquinoline-5-carbonitrile
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS FOR TREATING CORONAVIRUSES
  [FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT DES CORONAVIRUS

  摘要：

  This invention provides compounds for the inhibition of papain-like proteases (PLpros) for the inhibition of viruses, including compounds of formula (I"), and pharmaceutically acceptable salts thereof.

  公开号：

  WO2023064493A1

文献信息

• INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS
  申请人：Disarm Therapeutics, Inc.

  公开号：US20220008405A1

  公开（公告）日：2022-01-13

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.
• INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR
  申请人：Disarm Therapeutics, Inc.

  公开号：US20220072019A1

  公开（公告）日：2022-03-10

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.
• [EN] INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR<br/>[FR] INHIBITEURS DE SARM1 EN COMBINAISON AVEC NAD+ OU UN PRÉCURSEUR DE NAD+
  申请人：DISARM THERAPEUTICS INC

  公开号：WO2020081923A1

  公开（公告）日：2020-04-23

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and NAD+ or a NAD+ precursor.
• [EN] INHIBITORS OF SARM1 IN COMBINATION WITH NEUROPROTECTIVE AGENTS<br/>[FR] INHIBITEURS DE SARM1 EN COMBINAISON AVEC DES AGENTS NEUROPROTECTEURS
  申请人：DISARM THERAPEUTICS INC

  公开号：WO2020132045A1

  公开（公告）日：2020-06-25

  The present disclosure relates to methods of treating neurodegeneration and neurodegenerative diseases comprising administering to a subject in need thereof a combination of a SARM1 inhibitor and a neuroprotective agent.