trans-3,4-dimethyltetrahydropyran | 81554-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: trans-3,4-dimethyltetrahydropyran
• 英文别名: (3S,4R)-3,4-dimethyloxane
• CAS: 81554-10-1
• 化学式: C₇H₁₄O
• 分子量: 114.188
• InChiKey: WYQJZACIHYTKGC-RNFRBKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,3-二甲基戊烷-1,5-二醇 在 Amberlyst 15 作用下， 生成 cis-3,4-dimethyltetrahydropyran 、 trans-3,4-dimethyltetrahydropyran
  参考文献：
  名称：

  Conformational analysis. 42. Monosubstituted tetrahydropyrans

  摘要：

  DOI：

  10.1021/ja00377a015

文献信息

• POLYCYCLIC-CARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Gilead Sciences, Inc.

  公开号：US20160176870A1

  公开（公告）日：2016-06-23

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R 1 , R 2 and R 3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

  披露了用于治疗人类免疫缺陷病毒（HIV）感染的化合物。这些化合物具有以下的化学式（Ia）：包括立体异构体和其药用可接受的盐，其中A′、R1、R2和R3如本文所定义。还披露了与这些化合物的制备和使用相关的方法，以及包含这些化合物的药物组合物。
• POLYCYCLICCARBAMOYLPYRIDONE COMPOUNDS AND THEIR PHARMACEUTICAL USE
  申请人：Gilead Sciences, Inc.

  公开号：US20170119764A1

  公开（公告）日：2017-05-04

  Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (Ia): including stereoisomers and pharmaceutically acceptable salts thereof, wherein A′, R 1 , R 2 and R 3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• US9522912B2
  申请人：——

  公开号：US9522912B2

  公开（公告）日：2016-12-20
• US9795602B2
  申请人：——

  公开号：US9795602B2

  公开（公告）日：2017-10-24