3-[1-(2-Methyl-7,8-Dihydro-1,6,9-Trioxa-3-Aza-Cyclopenta[a]Naphthalen-8-Ylmethyl)-1,2,3,6-Tetrahydro-Pyridin-4-Yl]-1H-Indole-5-Carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 3-[1-(2-Methyl-7,8-Dihydro-1,6,9-Trioxa-3-Aza-Cyclopenta[a]Naphthalen-8-Ylmethyl)-1,2,3,6-Tetrahydro-Pyridin-4-Yl]-1H-Indole-5-Carbonitrile
• 英文别名: 3-[1-[(2-methyl-7,8-dihydro-[1,4]dioxino[2,3-g][1,3]benzoxazol-8-yl)methyl]-3,6-dihydro-2H-pyridin-4-yl]-1H-indole-5-carbonitrile
• 化学式: C₂₅H₂₂N₄O₃
• 分子量: 426.5
• InChiKey: SUMCPAUSORUXTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  87.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  [(8R)-2-Methyl-7,8-dihydro[1,4]dioxino[2,3-g][1,3]benzoxazol-8-yl]methyl 4-methylbenzenesulfonate 、 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile 、 富马酸 在 氮气 、 乙酸乙酯 、 碳酸氢钠 、 Brine 、 magnesium sulfate 、 silica gel 作用下， 以 二甲基亚砜 、 乙醇 为溶剂， 以to give 0.20 g of the (S)-enantiomer of the title compound as a yellow solid difumarate·0的产率得到3-[1-(2-Methyl-7,8-Dihydro-1,6,9-Trioxa-3-Aza-Cyclopenta[a]Naphthalen-8-Ylmethyl)-1,2,3,6-Tetrahydro-Pyridin-4-Yl]-1H-Indole-5-Carbonitrile
  参考文献：
  名称：

  Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene

  摘要：

  公式为1的化合物对于治疗抑郁症和其他疾病非常有用，例如强迫症、恐慌症、广泛性焦虑症、社交焦虑症、性功能障碍、进食障碍、肥胖症、由酒精或可卡因滥用引起的成瘾性障碍和相关疾病。

  公开号：

  US20020183354A1

文献信息

• ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZA-CYCLOPENTA[A]NAPHTHALENE
  申请人：Wyeth

  公开号：US20030134871A1

  公开（公告）日：2003-07-17

  Compounds of the formula: 1 useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

  这种化合物的公式：1可用于治疗抑郁症和其他疾病，如强迫症、恐慌发作、广泛性焦虑障碍、社交焦虑障碍、性功能障碍、进食障碍、肥胖症、由乙醇或可卡因滥用引起的成瘾障碍及相关疾病。
• Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1, 6,9-trioxa-3-aza-cyclopenta[a]naphthalene
  申请人：Wyeth

  公开号：US20030109562A1

  公开（公告）日：2003-06-12

  Compounds of the formula: 1 useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

  化合物的公式：1，可用于治疗抑郁症和其他疾病，如强迫症、惊恐障碍、广泛性焦虑症、社交焦虑症、性功能障碍、进食障碍、肥胖症、由乙醇或可卡因滥用引起的成瘾性障碍以及相关疾病。
• Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
  申请人：Wyeth

  公开号：US06617334B2

  公开（公告）日：2003-09-09

  Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

  该式化合物可用于治疗抑郁症和其他疾病，如强迫症、恐慌症、广泛性焦虑症、社交焦虑症、性功能障碍、进食障碍、肥胖症、由乙醇或可卡因滥用引起的成瘾性障碍及相关疾病。
• Intermediate for antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1, 6,9-trioxa-3-aza-cyclopenta [a]naphthalene
  申请人：Wyeth

  公开号：US06613913B2

  公开（公告）日：2003-09-02

  Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse and related illnesses.

  这种化合物的公式：对治疗抑郁症和其他疾病有用，如强迫症、恐慌症、广泛性焦虑症、社交焦虑症、性功能障碍、进食障碍、肥胖症、由乙醇或可卡因滥用引起的成瘾性障碍以及相关疾病。
• ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 7,8-DIHYDRO-1,6,9-TRIOXA-3-AZA-CYCLOPENTA(A)NAPHTHALENE
  申请人：Wyeth

  公开号：EP1392700B1

  公开（公告）日：2004-09-29