N,N'-Bis-(3,3-diphenyl-propyl)-succinamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis-(3,3-diphenyl-propyl)-succinamide
• 英文别名: N,N'-bis(3,3-diphenylpropyl)butanediamide
• 化学式: C₃₄H₃₆N₂O₂
• 分子量: 504.672
• InChiKey: AKPGCEBGYGASKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  38
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,3-二苯基丙胺 、 44-Methylidene-10,13,16,19,22,25,36,41-octaoxahexacyclo[32.8.3.02,7.09,42.026,35.028,33]pentatetraconta-1(42),2,4,6,8,26,28,30,32,34-decaene-37,40-dione 反应 16.0h， 以26%的产率得到N,N'-bis(3,3-diphenylpropyl)butanediamide;3-methylidene-14,17,20,23,26,29-hexaoxapentacyclo[28.7.1.15,13.06,11.032,37]nonatriaconta-1(38),5(39),6,8,10,12,30,32,34,36-decaene-38,39-diol
  参考文献：
  名称：

  通过串联克莱森重排，二酯化和氨解合成轮烷的新方法

  摘要：

  A novel methodology to make rotaxanes via covalent bond formation has been developed. Rotaxanes composed of crownophanes having two phenolic hydroxy groups as a molecular rotor and an axle having diamide moieties were synthesized in moderate yields via three step processes: tandem Claisen rearrangement, intramolecular diesterification, and aminolysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01201-7

文献信息

• A new synthetic method for rotaxanes via tandem Claisen rearrangement, diesterification, and aminolysis
  作者：Kazuhisa Hiratani、Jun-ichi Suga、Yoshinobu Nagawa、Hirohiko Houjou、Hideo Tokuhisa、Munenori Numata、Kunihiro Watanabe

  DOI：10.1016/s0040-4039(02)01201-7

  日期：2002.8

  A novel methodology to make rotaxanes via covalent bond formation has been developed. Rotaxanes composed of crownophanes having two phenolic hydroxy groups as a molecular rotor and an axle having diamide moieties were synthesized in moderate yields via three step processes: tandem Claisen rearrangement, intramolecular diesterification, and aminolysis. (C) 2002 Elsevier Science Ltd. All rights reserved.