3-[(3-carboxyphenyl)sulfinyl]benzenecarboxylic acid | 131073-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[(3-carboxyphenyl)sulfinyl]benzenecarboxylic acid
• 英文别名: 3-(3-carboxyphenyl)sulfinylbenzoic acid
• CAS: 131073-61-5
• 化学式: C₁₄H₁₀O₅S
• 分子量: 290.296
• InChiKey: MHHHKSFEQMVGJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,3'-thiodibenzoic acid 在 吡啶 、 phenyltrimethylammonium tribromide 作用下， 反应 24.0h， 以87%的产率得到3-[(3-carboxyphenyl)sulfinyl]benzenecarboxylic acid
  参考文献：
  名称：

  Phenyltrimethylammonium Tribromide for Selective Oxidation of Sulfides to Sulfoxides. A Convenient Synthesis of Sulfinyl-¹⁸O-Labelled Sulfoxide Carboxylic Acids

  摘要：

  多种硫化物可以在水相吡啶溶液中使用三溴化苯基三甲铵选择性地氧化为相应的亚硫酰氧化物，并且产率很高。这种方法允许制备18O标记的亚硫酰氧化物，且不损失所用(18O)水的同位素富集。

  DOI：

  10.1055/s-1990-27033

文献信息

• [EN] FC RECEPTOR MODULATING COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSES ET COMPOSITIONS MODULANT LE RECEPTEUR FC
  申请人：ARTHRON LTD

  公开号：WO2004058747A1

  公开（公告）日：2004-07-15

  The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcϜRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

  本发明提供了能够结合到Fc受体并调节Fc受体活性的化合物，包括以芳基环形式的核心疏水基团，该芳基环被富含p-电子的基团取代。本发明还提供了一种治疗自身免疫疾病涉及Fc受体活性的方法，使用这种化合物。还提供了一种获取调节Fc受体活性的化合物的方法，该方法包括：(a)提供或设计具有结构特征以适应FcϜRIIa结构凹槽的化合物；和(b)筛选这些化合物以调节Fc受体活性。
• Fc receptor modulating compounds and compositions
  申请人：Hogarth Mark Philip

  公开号：US20060264484A1

  公开（公告）日：2006-11-23

  The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl ring substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

  本发明提供了一种能够结合Fc受体并调节Fc受体活性的化合物，其中包括一个具有芳基环的核心亲脂性基团，该基团被取代为一个富含p电子的基团。本发明还提供了一种使用这些化合物治疗自身免疫性疾病的方法，该疾病涉及Fc受体活性。还提供了一种用于获得调节Fc受体活性的化合物的方法，该方法包括：(a)提供或设计具有适合于FcγRIIa结构凹槽的结构特征的化合物;和(b)筛选这些化合物对Fc受体的调节活性。
• Fc Receptor Modulating Compounds and Compositions
  申请人：Hogarth Mark Phillip

  公开号：US20080146632A1

  公开（公告）日：2008-06-19

  The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

  本发明提供了一种能够结合到Fc受体并调节Fc受体活性的化合物，包括一个具有芳基锌的核心亲脂基团，该芳基锌被富含p电子的基团取代。本发明还提供了一种使用这些化合物治疗自身免疫性疾病的方法，该疾病涉及Fc受体活性。本发明还提供了一种获得调节Fc受体活性的化合物的方法，该方法包括：（a）提供或设计具有结构特征以适合FcγRIIa结构凹槽的化合物；和（b）筛选具有调节Fc受体活性的化合物。
• Fc RECEPTOR MODULATING COMPOUNDS AND COMPOSITIONS
  申请人：Hogarth Mark Phillip

  公开号：US20110144170A1

  公开（公告）日：2011-06-16

  The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the FcγRIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.

  本发明提供了一种能够结合Fc受体并调节Fc受体活性的化合物，包括一个具有芳基锌取代基的亲脂性核心基团，该基团被富含p电子的基团所取代。本发明还提供了一种治疗自身免疫性疾病的方法，该方法涉及使用这些化合物来调节Fc受体活性。还提供了一种获得调节Fc受体活性的化合物的方法，该方法包括：(a)提供或设计具有适合于FcγRIIa结构凹槽的结构特征的化合物；(b)筛选这些化合物以获得对Fc受体的调节活性。
• Flame retarding resin composition
  申请人：——

  公开号：US20040077821A1

  公开（公告）日：2004-04-22

  Disclosed is a flame retarding resin composition comprising (A) one or more epoxy resins; (B) a hardener; and (C) a hardening accelerator, wherein the hardener of the component B is a phosphorus-containing compound represented by the following formula (I): 1 wherein each symbol is as defined below. The flame retarding resin composition of the present invention without adding halogen or other flame retardants has high flame retardancy and excellent heat resistance. The flame retarding resin composition of the present invention is suitably useful in the application of thermosetting resins, thermoplastic resins, bonding sheets, composite materials, laminated plates, printed circuit boards, copper foil adhesives, inks used for build-up process, semiconductor molding materials and the like.

  本发明公开了一种阻燃树脂组合物，该组合物包含(A)一种或多种环氧树脂；(B)一种固化剂；以及(C)一种硬化促进剂，其中成分 B 的固化剂是由下式(I)表示的含磷化合物： 1 其中各符号定义如下。本发明的阻燃树脂组合物不添加卤素或其他阻燃剂，具有高阻燃性和优异的耐热性。本发明的阻燃树脂组合物适用于热固性树脂、热塑性树脂、粘合片、复合材料、层压板、印刷电路板、铜箔粘合剂、用于堆积工艺的油墨、半导体成型材料等。