(+)-Ragaglitazar | 222834-30-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (+)-Ragaglitazar
• 英文别名: (R)-3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid；(-)-3-(4-(2-(Phenoxazin-10-yl)ethoxy)phenyl)-2-ethoxypropanoic acid；(2R)-2-ethoxy-3-[4-(2-phenoxazin-10-ylethoxy)phenyl]propanoic acid
• CAS: 222834-30-2
• 化学式: C₂₅H₂₅NO₅
• 分子量: 419.477
• InChiKey: WMUIIGVAWPWQAW-XMMPIXPASA-N

物化性质

• 熔点：
  89-90 °C
• 沸点：
  608.6±55.0 °C(Predicted)
• 密度：
  1.241±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  68.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (+)-Ragaglitazar 、 L-苯甘氨醇 在 L-苯甘氨醇 作用下， 以32的产率得到[(2S),N(1S)]-3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxy-N-(2-hydroxy-1-phenylethyl)propanamide
  参考文献：
  名称：

  [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. (中文翻译) 新型的公式（I）中的$g(b)-芳基-$g(a)-氧代取代烷基羧酸和含有它们的组合物。这些化合物具有降血脂和抗高血糖的作用。

  公开号：

  WO1999019313A1
• 作为产物：
  描述：

  (+/-) Ethyl 3-[4-[2-(phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoate 以77的产率得到(+)-Ragaglitazar
  参考文献：
  名称：

  [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  [FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT

  摘要：

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. (中文翻译) 新型的公式（I）中的$g(b)-芳基-$g(a)-氧代取代烷基羧酸和含有它们的组合物。这些化合物具有降血脂和抗高血糖的作用。

  公开号：

  WO1999019313A1

文献信息

• [EN] SUBSTITUTED XANTHINE DERIVATIVES<br/>[FR] DÉRIVÉS DE XANTHINE SUBSTITUÉS
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2013013052A1

  公开（公告）日：2013-01-24

  The present invention in one embodiment relates to a compound of Formula (I); or a pharmaceutically acceptable salt thereof, wherein: each of R1 and R2 is independently selected from -CH3 and -CD3; R3 is hydrogen or deuterium; each of Z1, Z2 and Z3 is independently selected from hydrogen and deuterium; each Z4 is hydrogen or deuterium; each Z5 is hydrogen or deuterium; and each Z6 is hydrogen or deuterium.

  在一个实施例中，本发明涉及一种化合物，其化学式为（I）；或其药用可接受的盐，其中：R1和R2中的每一个可独立选择自-CH3和-CD3；R3是氢或氘；Z1、Z2和Z3中的每一个可独立选择自氢和氘；每个Z4是氢或氘；每个Z5是氢或氘；每个Z6是氢或氘。
• Substituted xanthine derivatives
  申请人：Tung Roger D.

  公开号：US20090239886A1

  公开（公告）日：2009-09-24

  This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

  本发明涉及新型化合物，即取代黄嘌呤衍生物及其药学上可接受的盐。例如，本发明涉及新型取代黄嘌呤衍生物，它们是戊酰异丙基黄嘌呤的衍生物。本发明还提供了包含本发明中的一种或多种化合物和载体的组合物，以及把所述化合物和组合物用于治疗戊酰异丙基黄嘌呤和相关化合物有益的疾病和病况的方法。
• [EN] NOVEL TRICYCLIC COMPOUNDS AND THEIR USE IN MEDICINE; PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CES DERNIERS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：DR. REDDY'S RESEARCH FOUNDATION

  公开号：WO1999019313A1

  公开（公告）日：1999-04-22

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.(FR) La présente invention concerne de nouveaux acides alkylcarboxyliques $g(b)-aryl-$g(a)-oxysubstitués répondant à la formule (I) et des compositions les contenant. Ces composés sont utilisés comme agents hypolipémiants et antihyperglycémiants.

  (EN) Novel $g(b)-aryl-$g(a)-oxysubstituted alkylcarboxylic acids of formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses. (中文翻译) 新型的公式（I）中的$g(b)-芳基-$g(a)-氧代取代烷基羧酸和含有它们的组合物。这些化合物具有降血脂和抗高血糖的作用。
• Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
  申请人：Lohray Bhushan Braj

  公开号：US20060148793A1

  公开（公告）日：2006-07-06

  Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

  化合物公式为（I）的小说β-芳基-α-氧基取代烷基羧酸及含有它们的组合物。这些化合物具有降血脂、降血糖的用途。
• Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
  申请人：Dr. Reddy's Research Foundation

  公开号：US07119198B2

  公开（公告）日：2006-10-10

  Novel β-aryl-α-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.

  新型的β-芳基-α-氧基取代烷基羧酸（I）及含有它们的组合物。这些化合物具有降血脂、抗高血糖的用途。