azomethine-H monosodium salt | 5941-07-1

• 物质功能分类: 化学试剂 - 有机试剂 - 磺酸盐/亚磺酸盐
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: azomethine-H monosodium salt
• 英文别名: azomethine H sodium salt；azomethin-H monosodium salt；sodium hydrogen 4-hydroxy-5-(salicylideneamino)naphthalene-2,7-disulphonate；Sodium;hydron;4-hydroxy-5-[(2-hydroxyphenyl)methylideneamino]naphthalene-2,7-disulfonate；sodium;hydron;4-hydroxy-5-[(2-hydroxyphenyl)methylideneamino]naphthalene-2,7-disulfonate
• CAS: 5941-07-1
• 化学式: C₁₇H₁₂NO₈S₂*Na
• 分子量: 445.406
• InChiKey: VDMRMECRCLGIAD-UHFFFAOYSA-M

物化性质

• 熔点：
  >300°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）
• 稳定性/保质期：
  在常温常压下，这种物质是一种稳定的鲜橙色结晶性粉末，熔点为300℃（分解），pH值约为5，最大吸收波长为415nm。它对眼睛、呼吸系统和皮肤具有刺激性。市售商品通常会制成钠盐，并含有x分子的结晶水。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.84
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  181
• 氢给体数：
  3
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  32041400
• 危险性防范说明：
  P264,P280,P302+P352+P332+P313+P362+P364,P305+P351+P338+P337+P313
• 危险性描述：
  H315,H319

制备方法与用途

生物活性

Azomethine-H monosodium 是一种成色试剂，同时也常用于测定硼。

体外研究

Azomethine-H monosodium 主要用于手动测定复杂硼化物和硼烷中的硼含量。

用途

• 用于光度法测定硼。
• 作为测硼的光谱试剂。

反应信息

• 作为反应物：
  描述：

  azomethine-H monosodium salt 在 甲醇 、 sodium tetrahydroborate 作用下， 反应 2.0h， 以80%的产率得到4-(2-hydroxybenzylamino)-5-hydroxynaphthalene-2,7-disulfonic acid
  参考文献：
  名称：

  A copper(II) complex as selective turn-on fluorosensor for nitric oxide and its intracellular application

  摘要：

  A highly water soluble copper(II) complex, 1 of a fluorophore ligand 4-(2-hydroxybenzylamino)-5 -hydroxynaphthalene-2,7-disulfonic acid (FL1) was synthesized and characterized. In the complex, the fluorescence intensity of the ligand was found to quench due to the presence of paramagnetic Cu(II) center. In degassed methanol solution of complex 1, the Cu(II) center was found to undergo reduction in presence of nitric oxide. This resulted in the simultaneous formation of N-nitrosated ligand. In the process, the quenched fluorescence intensity of the ligand restored. The selective turn on fluorogenic nature of the complex 1 was used to study the endogenously produced NO in living cells. (C) 2015 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2015.08.014

文献信息

• A copper(II) complex as selective turn-on fluorosensor for nitric oxide and its intracellular application
  作者：Kanhu Charan Rout、Sumit Kumar Chaturvedi、Rizwan Hasan Khan、Biplab Mondal

  DOI：10.1016/j.ica.2015.08.014

  日期：2015.10

  A highly water soluble copper(II) complex, 1 of a fluorophore ligand 4-(2-hydroxybenzylamino)-5 -hydroxynaphthalene-2,7-disulfonic acid (FL1) was synthesized and characterized. In the complex, the fluorescence intensity of the ligand was found to quench due to the presence of paramagnetic Cu(II) center. In degassed methanol solution of complex 1, the Cu(II) center was found to undergo reduction in presence of nitric oxide. This resulted in the simultaneous formation of N-nitrosated ligand. In the process, the quenched fluorescence intensity of the ligand restored. The selective turn on fluorogenic nature of the complex 1 was used to study the endogenously produced NO in living cells. (C) 2015 Elsevier B.V. All rights reserved.

表征谱图