(+/-)-cis-13-hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (+/-)-cis-13-hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one
• 英文别名: (1S,12R)-13-(hydroxymethyl)-13-azabicyclo[10.2.0]tetradecan-14-one
• 化学式: C₁₄H₂₅NO₂
• 分子量: 239.358
• InChiKey: FWMOZDJWJQKICM-QWHCGFSZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (+/-)-cis-13-azabicyclo[10.2.0]tetradecan-14-one 在 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 8.0h， 以77%的产率得到(+/-)-cis-13-hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one
  参考文献：
  名称：

  Lipase-catalyzed kinetic resolution of 7-, 8- and 12-membered alicyclic β-amino esters and N-hydroxymethyl-β-lactam enantiomers

  摘要：

  Enzymatic kinetic resolutions of methyl cis-2-aminocycloheptane-, 2-aminocyclooctane- and 2-aminocyclododecanecarboxylates with Candida antarctica lipase A in diisopropyl ether (E > 200) and of the corresponding N-hydroxymethyl-beta-lactams with Pseudomonas cepacia lipase in dry acetone (E from 27 to > 200) has been performed with 2,2,2-trifluoroethyl butanoate as the best acyl donor, with both enantiomers being obtained. trans-13-Hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one was resolved with vinyl butanoate and Candida antarctica lipase B (E=26) in acetone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2003.08.028

文献信息

• Lipase-catalyzed kinetic resolution of 7-, 8- and 12-membered alicyclic β-amino esters and N-hydroxymethyl-β-lactam enantiomers
  作者：Zsuzsanna Cs. Gyarmati、Arto Liljeblad、Mikko Rintola、Gábor Bernáth、Liisa T. Kanerva

  DOI：10.1016/j.tetasy.2003.08.028

  日期：2003.11

  Enzymatic kinetic resolutions of methyl cis-2-aminocycloheptane-, 2-aminocyclooctane- and 2-aminocyclododecanecarboxylates with Candida antarctica lipase A in diisopropyl ether (E > 200) and of the corresponding N-hydroxymethyl-beta-lactams with Pseudomonas cepacia lipase in dry acetone (E from 27 to > 200) has been performed with 2,2,2-trifluoroethyl butanoate as the best acyl donor, with both enantiomers being obtained. trans-13-Hydroxymethyl-13-azabicyclo[10.2.0]tetradecan-14-one was resolved with vinyl butanoate and Candida antarctica lipase B (E=26) in acetone. (C) 2003 Elsevier Ltd. All rights reserved.