tert-butyl 4-(hydroxymethyl)-1H-indazole-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: tert-butyl 4-(hydroxymethyl)-1H-indazole-1-carboxylate
• 英文别名: Tert-butyl 4-(hydroxymethyl)-1H-indazole-1-carboxylate；tert-butyl 4-(hydroxymethyl)indazole-1-carboxylate
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: ZAIKRESILISGDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 4-(hydroxymethyl)-1H-indazole-1-carboxylate 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 以180 mg的产率得到tert-butyl 4-(chloromethyl)-1H-indazole-1-carboxylate
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS

  摘要：

  The invention relates to compounds of formula (la) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: Formula (Ia) wherein RA, RB, RCand RD, X, m and n are as defined herein.

  公开号：

  WO2023052783A1
• 作为产物：
  描述：

  (1H-吲唑-4-基)甲醇 、 二碳酸二叔丁酯 在 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 生成 tert-butyl 4-(hydroxymethyl)-1H-indazole-1-carboxylate
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS
  [FR] NOUVEAUX COMPOSÉS

  摘要：

  The invention relates to compounds of formula (la) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: Formula (Ia) wherein RA, RB, RCand RD, X, m and n are as defined herein.

  公开号：

  WO2023052783A1

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：[en]SITRYX THERAPEUTICS LIMITED

  公开号：WO2023052783A1

  公开（公告）日：2023-04-06

  The invention relates to compounds of formula (la) and to their use in treating or preventing an inflammatory disease, a disease associated with an undesirable immune response, cancer, obesity, a diabetic disease or a blood disorder: Formula (Ia) wherein RA, RB, RCand RD, X, m and n are as defined herein.