salmon MCH

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: salmon MCH
• 英文别名: 4-[[2-[[24-[[2-[[2-[[2-[(2-amino-3-carboxypropanoyl)amino]-3-hydroxybutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3,12-bis[3-(diaminomethylideneamino)propyl]-6-[(4-hydroxyphenyl)methyl]-21-(2-methylsulfanylethyl)-2,5,8,11,14,17,20,23,31-nonaoxo-9,18-di(propan-2-yl)-26,27-dithia-1,4,7,10,13,16,19,22,30-nonazabicyclo[30.3.0]pentatriacontane-29-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[(1-carboxy-2-methylpropyl)amino]-5-oxopentanoic acid
• 化学式: C₈₉H₁₃₉N₂₇O₂₄S₄
• 分子量: 2099.5
• InChiKey: ORRDHOMWDPJSNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  144
• 可旋转键数：
  46
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  945
• 氢给体数：
  28
• 氢受体数：
  32

反应信息

• 作为反应物：
  描述：

  2-(4-bromophenyl)-1-(4-chlorophenyl)pentan-1-ol 、 salmon MCH 在 1-bromo-4-(2-(4-chlorophenyl)-1-propylpent-4-en-1-yl)benzene 作用下， 以The title compound is obtained as a 2.1:1 mixture of diastereomers的产率得到1-bromo-4-(2-(4-chlorophenyl)-1-propylpent-4-en-1-yl)benzene
  参考文献：
  名称：

  Glucagon receptor antagonist compounds, compositions containing such compounds and methods of use

  摘要：

  披露了胰高血糖素受体拮抗剂化合物。这些化合物对于治疗2型糖尿病及相关疾病非常有用。还包括药物组成物和治疗方法。

  公开号：

  US07968589B2

文献信息

• GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Stelmach John E.

  公开号：US20100004158A1

  公开（公告）日：2010-01-07

  Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included. (I)

  本文披露了一种胰高血糖素受体拮抗剂化合物。该化合物可用于治疗2型糖尿病及相关疾病。本文还包括制药组合物和治疗方法。
• Substituted Imidazole 4-Carboxamides as Cholecystokinin-1 Receptor Modulators
  申请人：Berger Richard

  公开号：US20090239862A1

  公开（公告）日：2009-09-24

  Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1, such as obesity, and diabetes.

  某些新型取代咪唑4-羧酰胺是人胆囊收缩素受体的配体，尤其是人胆囊收缩素-1受体（CCK-1R）的选择性配体。它们因此可用于治疗、控制或预防对CCK-1调节敏感的疾病和疾病，如肥胖症和糖尿病。
• Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators
  申请人：Merck Sharp & Dohme Corp.

  公开号：US07858629B2

  公开（公告）日：2010-12-28

  Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

  某些新型取代咪唑4-羧酰胺是人类胆囊收缩素受体的配体，特别是人类胆囊收缩素-1受体（CCK-1R）的选择性配体。它们因此可用于治疗、控制或预防对CCK-1R调节敏感的疾病和障碍，如肥胖症和糖尿病。
• Substituted Aminopyrimidines as Cholecystokinin-1 Receptor Modulators
  申请人：Edmondson Scott

  公开号：US20100113492A1

  公开（公告）日：2010-05-06

  Certain novel substituted aminopyrimidines are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

  某些新型取代氨基嘧啶是人体胆囊收缩素受体的配体，特别是人体胆囊收缩素-1受体（CCK-1R）的选择性配体。因此，它们对于治疗、控制或预防对CCK-1R调节敏感的疾病和疾病是有用的，例如肥胖症和糖尿病。
• Substituted imidazoles as bombesin receptor subtype-3 modulators
  申请人：Dobbelaar Peter H.

  公开号：US20100204236A1

  公开（公告）日：2010-08-12

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹肽受体的配体，特别是人类炸弹肽受体亚型-3（BRS-3）的选择性配体。因此，它们可用于治疗、控制或预防对BRS-3调节敏感的疾病和障碍，例如肥胖症和糖尿病。