3-amino-azacyclotridecan-2-one | 129385-03-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 3-amino-azacyclotridecan-2-one
• CAS: 129385-03-1
• 化学式: C₁₂H₂₄N₂O
• 分子量: 212.335
• InChiKey: CQZLEYBEPASILI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-(S)-dibenzyloxyphosphinylpropyl)-(S)-leucine 、 3-amino-azacyclotridecan-2-one 在 palladium on charcoal 作用下， 生成 3-[N-[N-((S)-1-phosphonopropyl)-(S)-leucyl]]-(-)-aminoazacyclotridecan-2-one
  参考文献：
  名称：

  US5212163

  摘要：

  公开号：

文献信息

• Mercapto-phenylalcanoylamino acid amides, their preparation and their use as collagenase inhibitors
  申请人：BEECHAM GROUP PLC

  公开号：EP0358305A1

  公开（公告）日：1990-03-14

  Novel compounds of formula (I), salts, solvates and hydrates thereof: in which: R1 and R2 are independently hydrogen; alkyl; alkoxy; halogen; or CF3; R3 is hydrogen; acyl, such as where Z is optionally substituted aryl; or a group R-S- where R is an organic residue such that the group R-S- provides an in vivo-cleavable disulphide bond; R4. is C3-6 alkyl; Rs is hydrogen; alkyl; -CH2-R10 where R10 is optionally substituted phenyl or heteroaryl; or a group where R11 is hydrogen; alkyl; or -CH2-Ph where Ph is optionally substituted phenyl; and R12 is hydrogen or alkyl; and Rs is hydrogen; alkyl; or a group where R13 is hydrogen; or alkyl; and R14 is hydroxy; alkoxy; or -NR7R8 where each of R7 and R8 is hydrogen or alkyl, or R7 and R8 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7- membered ring with an optional oxygen, sulphur or optionally substituted nitrogen atom in the ring; or Rs and R6 are joined together as -(CH2)m- where m is an integer from 4 to 12; X is (CHz)n where n is 0, 1, or 2; and Y is CH2, processes for their preparation and their use as collagenase inhibitors.

  式 (I) 的新型化合物及其盐类、溶液和水合物： 其中 R1 和 R2 独立地为氢、烷基、烷氧基、卤素或 CF3； R3 是氢；酰基，如 其中 Z 是任选取代的芳基；或基团 R-S-，其中 R 是有机残基，使基团 R-S- 提供体内可裂解的二硫键； R4.是 C3-6 烷基； Rs 是氢；烷基；-CH2-R10，其中 R10 是任选取代的苯基或杂芳基； 或一个基团 R11 是氢；烷基；或-CH2-Ph，其中 Ph 是任选取代的苯基；和 R12 是氢或烷基；和 Rs 是氢；烷基；或一个基团 R13是氢；或烷基；和R14是羟基；烷氧基；或-NR7R8，其中R7和R8各自是氢或烷基，或R7和R8与它们所结合的氮原子一起形成一个5、6或7个成员的环，环中有一个任选的氧、硫或任选取代的氮原子； 或 Rs 和 R6 连接成-( )m-，其中 m 为 4 至 12 的整数； X是(CHz)n，其中n是0、1或2；Y是 ，它们的制备工艺和作为胶原酶抑制剂的用途。
• Phosphonopeptides with collagenase inhibiting activity
  申请人：Beecham Group p.l.c.

  公开号：EP0401963A1

  公开（公告）日：1990-12-12

  Novel compounds of formula (I) and salts, solvates and hydrates thereof, processes for their preparation and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: in which, R is hydrogen, C₁₋₆ alkyl or optionally substituted benzyl; R₁ is hydrogen or C₁₋₆ alkyl; R₂ is C₃₋₆ alkyl; R₃ is hydrogen, alkyl, -CH₂-Z where Z is optionally substituted phenyl or heteroaryl, or R₃ is a group where R₇ is hydrogen, alkyl or -CH₂-Ph where Ph is optionally substituted phenyl and R₈ is hydrogen or alkyl; and R₄ is -CH₂-(CH₂)nOR₅ or -CH₂-(CH₂)nOCOR₆ or -CH(R₉)COR₁₀, where n is an integer from 1 to 6; R₅, R₆ and R₉ are hydrogen or C₁₋₆ alkyl; and R₁₀ is hydroxy or -O-C₁₆ alkyl or -NR₅R₆ (where R₅ and R₆ may be linked to form a heterocyclic ring; or R₃ and R₄ are joined together as -(CH₂)m- where m is an integer from 4 to 12.

  式(I)的新型化合物及其盐类、溶液和水合物，其制备工艺以及在治疗结缔组织和身体其他蛋白成分降解的病症中的用途： 其中，R 是氢、C₁₋₆烷基或任选取代的苄基；R₁ 是氢或 C₁₋₆ 烷基；R₂ 是 C₃₋₆烷基； R₃ 是氢、烷基、-CH₂-Z（其中 Z 是任选取代的苯基或杂芳基）或 R₃ 是一个基团 其中 R₇ 是氢、烷基或 -CH₂-Ph，其中 Ph 是任选取代的苯基，R₈ 是氢或烷基；R₄是-CH₂-(CH₂)nOR₅或-CH₂-(CH₂)nOCOR₆或-CH(R₉)COR₁₀，其中 n 是 1 到 6 的整数；R₅、R₆ 和 R𠢙 是氢或 C₁₋₆ 烷基；且 R₁₀ 是羟基或 -O-C₁₆ 烷基或 -NR₅R₆ （其中 R₅ 和 R₆ 可连接形成杂环；或 R₃ 和 R₄ 连接成-(CH₂)m-，其中 m 为 4 至 12 的整数。
• N-(2-oxoazacycloalkyl) glutarylamide derivatives and their use as collagenase inhibitors
  申请人：Beecham Group p.l.c.

  公开号：EP0438223A1

  公开（公告）日：1991-07-24

  Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: in which, R₁ is -OH; alkoxy; aryloxy or aralkyloxy in each of which the aryl group is optionally substituted; -NR₆R₇, where each of R₆ and R₇ is independently hydrogen or alkyl, or R₆ and R₇ together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring; or a group: -NH-CH(R₈)-C(O)-R₉ where R₈ is hydrogen; alkyl optionally substituted by -OH, alkoxy, -NR₆R₇ as defined for R₁, guanidine, -CO₂H, -CONH₂, -SH, or -S-alkyl; or -CH₂-Ar where Ar is optionally substituted aryl or heteroaryl; and R₉ is alkoxy; -OH; or -NR₆R₇ as defined for R₁; R₂ is hydrogen; C₂₋₈ alkanoyl; or optionally substituted aroyl; R₃ is C₃₋₆ alkyl; and R₄ is -(CH₂)m- where m is an integer from 4 to 12.

  式 (I) 的新型化合物及其药学上可接受的盐；它们的制备方法；含有它们的组合物；以及它们在治疗结缔组织和身体其他蛋白质成分发生降解的病症中的用途： 其中，R₁ 是-OH；烷氧基；芳氧基或芳烷氧基，其中芳基任选被取代；-NR₆R₇，其中每个 R₆ 和 R₇ 独立为氢或烷基，或 R₆ 和 R₇ 与它们所键合的氮原子一起形成 5、6 或 7 元环，环中有任选的氧原子或硫原子或任选取代的第二个氮原子；或一个基团：-NH-CH（R₈）-C（O）-R₉ 其中 R₈ 是氢；任选被-OH、烷氧基、R₁ 所定义的-NR₆R₇、胍、-CO₂H、-CONH₂、-SH 或-S-烷基取代的烷基；或-CH₂-Ar，其中 Ar 是任选取代的芳基或杂芳基；且 R𠢙 是烷氧基；-OH；或如 R₁ 所定义的-NR₆R₇； R₂ 是氢；C₂₋₈ 烷酰基；或任选取代的芳基； R₃ 是 C₃₋₆烷基；和 R₄ 是-(CH₂)m-，其中 m 是 4 至 12 的整数。
• PHOSPHONOPEPTIDES WITH COLLAGENASE INHIBITING ACTIVITY
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0612324A1

  公开（公告）日：1994-08-31
• ANTIBACTERIAL AGENTS
  申请人：BRITISH BIOTECH PHARMACEUTICALS LIMITED

  公开号：EP1165532A1

  公开（公告）日：2002-01-02