9-octadecenyl monoethanolamine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 9-octadecenyl monoethanolamine
• 英文别名: 2-(9-Octadecenylamino)-1-ethanol；2-(octadec-9-enylamino)ethanol
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: ZMOMBHNITWAALH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  油酰氯 、 C.I.酸性橙108 反应 5.0h， 生成 9-octadecenyl monoethanolamine
  参考文献：
  名称：

  ANIONIC-CATIONIC-NONIONIC SURFACTANT,PRODUCTION AND USE THEREOF

  摘要：

  这项发明涉及一种阴离子-阳离子-非离子表面活性剂，其大致由式(I)所代表，以及该表面活性剂在三次采油中的生产和使用。该发明的阴离子-阳离子-非离子表面活性剂与现有技术相比具有明显改善的界面活性和稳定性。采用这种阴离子-阳离子-非离子表面活性剂，可以制备出用于三次采油的注水液组成物，其具有比现有技术更高的油位移效率和油洗能力。在式(I)中，每个基团如规范中所定义。

  公开号：

  US20170313928A1

文献信息

• COMPOSITION FOR PROMOTING HAIR GROWTH OR PREVENTING HAIR LOSS
  申请人：NEOPHARM CO., LTD.

  公开号：US20160354293A1

  公开（公告）日：2016-12-08

  The present invention relates to a composition for promoting hair growth, preventing hair loss, or relieving inflammation, and more specifically, to a composition which has excellent stability to the skin, has no side effects, and exhibits excellent effects of hair growth promotion and hair loss prevention by promoting hair growth and delaying hair loss. The composition according to the present invention contains a material belonging to a ceramidase inhibitor, glycol, C1-C5 lower alcohol, and water, and thus the composition is safe, has no side effects, can be continuously used for a long period of time, has an excellent effect of hair growth promotion or hair loss prevention by significantly promoting hair growth, and exhibits an inflammation relieving effect as well as a hair growth promoting effect, additionally.

  本发明涉及一种促进头发生长、预防脱发或缓解炎症的组合物，更具体地说，涉及一种对皮肤具有优异稳定性、无副作用，并通过促进头发生长和延缓脱发而展现出优异的促进头发生长和预防脱发的效果的组合物。根据本发明的组合物含有属于酯酶抑制剂、甘醇、C1-C5低级醇和水的材料，因此该组合物安全、无副作用，可长期连续使用，通过显著促进头发生长，具有出色的促进头发生长或预防脱发的效果，并表现出缓解炎症以及促进头发生长的效果。
• MODULATION OF N-ACYLETHANOLAMINE-HYDROLYSING ACID AMIDASE (NAAA) FOR DISEASE TREATMENT
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US20190135802A1

  公开（公告）日：2019-05-09

  Pharmaceutical compositions make up a compound acting as inhibitor of N-acylethanolamine-hydrolysing acid amidase (NAAA), may be used for the therapeutical treatment and prevention of pain and inflammatory disorders and other disorders which benefit from the modulation of fatty acid ethanolamines, particularly palmitoylethanolamide (PEA). The compound is used in methods of inhibiting NAAA and methods of therapeutical treatment and prevention of pain and inflammation.

  药物组合物构成一种作为N-酰乙醇胺水解酸酶（NAAA）抑制剂的化合物，可用于治疗和预防疼痛和炎症性疾病以及其他受益于脂肪酸乙醇胺调节的疾病，特别是棕榈酰乙醇胺（PEA）。该化合物用于抑制NAAA的方法以及治疗和预防疼痛和炎症的方法。
• Arylalklcarbamate derivatives, preparation method thereof and use of same in therapeutics
  申请人：Abouabdellah Ahmed

  公开号：US20060223805A1

  公开（公告）日：2006-10-05

  The invention relates to a compound having general formula (I): Wherein n, A, R 1 , R 2 , and R 3 are as defined herein. The invention also relates to methods of preparation of compound of formula (I) as well as its use in therapeutics.

  本发明涉及具有一般式(I)的化合物：其中n，A，R1，R2和R3的定义如本文所述。本发明还涉及制备式(I)化合物的方法以及其在治疗学中的用途。
• Amine derivative and dermatologic preparation containing the same
  申请人：Kao Corporation

  公开号：US05723497A1

  公开（公告）日：1998-03-03

  The present invention relates to an amine derivative represented by the following general formula (I) or (II): ##STR1## wherein R.sup.1 means a heteroatom-containing C.sub.1 -C.sub.40 hydrocarbon group which may have a ring structure, or the like; R.sup.2 -R.sup.5 each denote a C.sub.1 -C.sub.20 hydrocarbon group, hydrogen or the like; A.sup.1 represents ##STR2## or R.sup.15 --Z--.sup.16 --(CH.sub.2).sub.n --; B.sup.1 stands for hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen or the like; C.sup.1 denotes hydrogen, a C.sub.1 -C.sub.10 hydrocarbon group, nitrogen, alcohol residue, phosphoric acid residue or the like; a dermatologic preparation containing the same; and a process for producing the amine derivative. This amine derivative has excellent effects of smoothing or removing wrinkles and improving keratinization.

  本发明涉及以下通式（I）或（II）所表示的胺衍生物：##STR1## 其中，R1表示含杂原子的C1-C40的烃基，可能具有环结构等；R2-R5各自表示C1-C20的烃基、氢或类似物；A1表示##STR2## 或R15-Z16-(CH2)n-；B1表示氢、C1-C10的烃基、氮或类似物；C1表示氢、C1-C10的烃基、氮、醇残基、磷酸残基或类似物；以及含有该胺衍生物的皮肤科制剂；以及制备该胺衍生物的方法。该胺衍生物具有优异的平滑或去除皱纹和改善角质化的效果。
• Cosmetic Composition Containing Calcium Citrate And N-Acylated Aminoalcohol Derivative To Prevent Dry Skin And Signs Of Cutaneous Ageing
  申请人：Moussou Philippe

  公开号：US20120016032A1

  公开（公告）日：2012-01-19

  Cosmetic compositions comprising calcium citrate and at least one N-acylated aminoalcohol according to formula (I). Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of Formula (I) in an amount effective to provide an anti-ageing effect. The compound of Formula (I) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing. The N-acylated aminoalcohol of formula (I) acts as a ceramidase inhibitor. The combination of at least one compound of formula (I) and calcium citrate stimulates keratinocyte differentiation.

  含有柠檬酸钙和至少一种按照公式（I）的N-酰化氨基醇的化妆品组合物。提供了一种治疗老化皮肤的方法，包括将公式（I）的化合物以有效量局部涂抹于老化皮肤上，以提供抗衰老效果。公式（I）的化合物用于防止皮肤老化和/或帮助维持或改善水分保持和/或对抗皮肤老化迹象。公式（I）的N-酰化氨基醇作为角鲨烷酸酶抑制剂。至少一种公式（I）化合物和柠檬酸钙的组合刺激角质细胞分化。