1-(2-氯苯基)哌嗪二盐酸盐 | 76835-05-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 1-(2-氯苯基)哌嗪二盐酸盐
• 英文名称: 1-(2-Chlorophenyl)piperazine dihydrochloride
• 英文别名: 1-(2-chlorophenyl)piperazine;dihydrochloride
• CAS: 76835-05-7
• 化学式: C10H15Cl3N2
• 分子量: 269.6
• InChiKey: UBXIECYGXFARTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-(3-chloropropoxy)chromen-4-one 、 1-(2-氯苯基)哌嗪二盐酸盐 、 碳酸氢钠 在 碘化钠 水 、 二氯甲烷 、 盐酸 、 甲醇 、 乙醇乙酸乙酯 、 hydrochloride salt 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以to yield 3.2 g of 7-[3-(4-(2-chlorophenyl)-1-piperazinyl)propoxy]-4H-1-benzopyran-4-one as its hydrochloride salt, mp 201°-203° C. (dec)的产率得到7-[3-(4-(2-chlorophenyl)-1-piperazinyl)propoxy]-4H-1-benzopyran-4-one
  参考文献：
  名称：

  4H-1-benzopyran-4-ones and their sulfur containing analogs

  摘要：

  本发明揭示了一种有效治疗精神病，包括精神分裂症的Novel 4H-1-苯并吡喃-4-酮及其含硫类似物。

  公开号：

  US04678787A1

文献信息

• PYRROLOPYRIMIDONE AND PYRROLOPYRIDONE INHIBITORS OF TANKYRASE
  申请人：Genentech, Inc.

  公开号：US20130331375A1

  公开（公告）日：2013-12-12

  There are provided compounds of the formula (I) wherein Q, R 1 and R 2 are defined herein. The compounds have activity as anticancer agents.

  提供了化合物的结构式(I)，其中Q、R1和R2的定义如下。这些化合物具有抗癌活性。
• 3-[4-(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US04933453A1

  公开（公告）日：1990-06-12

  3-[4-1-substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

  这是一种3-[4-1-取代基-4-哌嗪基)丁基]-4-噻唑啉酮化合物，可用作抗精神病、镇痛、抗惊厥和抗焦虑药物。
• 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related
  申请人：Hoechst-Roussel Pharmaceuticals Incorporated

  公开号：US05229388A1

  公开（公告）日：1993-07-20

  There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkylthio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

  公开了化合物的结构式，其中n为0、1或2；A为##STR2##其中每次出现的X独立地为氢、卤素、低碳基、羟基、硝基、低碳氧基、氨基、氰基、三氟甲基或甲硫基；每次出现的Y独立地为氢、卤素、低碳基、羟基、硝基、低碳氧基、氨基、氰基、三氟甲基或甲硫基；m为1或2；k为1或2；R.sub.1和R.sub.2独立地为氢、低碳基、##STR3##或芳基，但当R.sub.1为##STR4##或芳基时，R.sub.2为氢，或者R.sub.1+R.sub.2与它们所附着的碳原子结合形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、茚烷或哌啶环；R.sub.3和R.sub.4独立地为氢或低碳基，或者R.sub.3+R.sub.4与它们所附着的碳原子结合形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、吡咯烷或哌啶环，术语芳基表示未取代的苯基或取代有1、2或3个取代基的苯基，每个取代基独立地为低碳基、低碳氧基、羟基、卤素、低碳硫基、氰基、氨基或三氟甲基，这些化合物可用作抗精神病、镇痛、抗癫痫和抗焦虑剂。
• Arginine derivatives and pharmaceutically acceptable acid addition salts
  申请人：Mitsubishi Chemical Industries Limited

  公开号：US04764618A1

  公开（公告）日：1988-08-16

  Novel arginine derivatives represented by the general formula ##STR1## wherein R.sup.1 stands for a naphthalenesulfonyl, a naphthalenecarbonyl, a 1,2,3,4-tetrahydronaphthalenesulfonyl, a 1,2,3,4-tetrahydronaphthalenecarbonyl, a dioxa b-6,7-naphthalenesulfonyl, a dioxa b-6,7-naphthalenecarbonyl, a 1,2,3,4-tetrahydro-8-quinolinesulfonyl, a 1,2,3,4-tetrahydro-8-quinolinecarbonyl, a dibenzofuransulfonyl, a dibenzofurancarbonyl, a fluorenesulfonyl, a fluorenecarbonyl, a dibenzothiophenesulfonyl or a dibenzothiophene, and R.sup.2 stands for a piperidino or a piperazino are disclosed. These arginine derivatives and their pharmaceutically acceptable salts have trypsin-inhibiting activity and useful as a pancreatitis remedy.

  本发明揭示了由一般式##STR1##所代表的新的精氨酸衍生物，其中R.sup.1代表萘磺酰基，萘甲酰基，1,2,3,4-四氢萘磺酰基，1,2,3,4-四氢萘甲酰基，二氧a-b-6,7-萘磺酰基，二氧a-b-6,7-萘甲酰基，1,2,3,4-四氢-8-喹啉磺酰基，1,2,3,4-四氢-8-喹啉甲酰基，二苯并呋喃磺酰基，二苯并呋喃甲酰基，芴磺酰基，芴甲酰基，二苯并噻吩磺酰基或二苯并噻吩，R.sup.2代表哌啶基或哌嗪基。这些精氨酸衍生物及其药学上可接受的盐具有胰蛋白酶抑制活性，可用作胰腺炎的治疗剂。
• 3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone compounds
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05037984A1

  公开（公告）日：1991-08-06

  There are disclosed compounds of the formula ##STR1## where n is 0 or 1; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; Y in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy, amino, cyano, trifluoromethyl or methylthio; m is 1 or 2; k is 1 or 2; R.sub.1 and R.sub.2 are independently hydrogen, loweralkyl, ##STR3## or aryl except that when R.sub.1 is ##STR4## or aryl, R.sub.2 is hydrogen, or alternatively R.sub.1 +R.sub.2 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, indan or piperidine ring; R.sub.3 and R.sub.4 are independently hydrogen or loweralkyl, or alternatively R.sub.3 +R.sub.4 taken together with the carbon atom to which they are attached form a cyclopentane, cyclohexane, cycloheptane, pyran, thiopyran, pyrrolidine or piperidine ring, the term aryl signifying an unsubstituted phenyl group or a phenyl group substituted with 1, 2 or 3 substituents each of which being independently loweralkyl, loweralkoxy, hydroxy, halogen, loweralkythio, cyano, amino or trifluoromethyl, which are useful as antipsychotic, analgesic, anticonvulsant and anxiolytic agents.

  公开了化合物的式子##STR1##其中n为0或1; A为##STR2##其中每个X独立地为氢、卤素、低碳基羟基、硝基、低碳基氧基、氨基、氰基、三氟甲基或甲硫基;每个Y独立地为氢、卤素、低碳基、羟基、硝基、低碳基氧基、氨基、氰基、三氟甲基或甲硫基;m为1或2;k为1或2;R.sub.1和R.sub.2独立地为氢、低碳基、##STR3##或芳基，但当R.sub.1为##STR4##或芳基时，R.sub.2为氢，或者R.sub.1+R.sub.2与它们附着的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、茚烷或哌啶环;R.sub.3和R.sub.4独立地为氢或低碳基，或者R.sub.3+R.sub.4与它们附着的碳原子一起形成环戊烷、环己烷、环庚烷、吡喃、硫代吡喃、吡咯烷或哌啶环，术语芳基表示未取代的苯基或取代了1、2或3个基团的苯基，每个基团独立地为低碳基、低碳氧基、羟基、卤素、低碳硫基、氰基、氨基或三氟甲基，这些化合物可用作抗精神病、镇痛、抗癫痫和抗焦虑药物。