4-N-pyrrolidinyl N'-ethyl 1,8-naphthalimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-N-pyrrolidinyl N'-ethyl 1,8-naphthalimide
• 英文别名: 2-ethyl-6-(pyrrolidin-1-yl)-1H-benzo[de]isoquinoline-1,3(2H)-dione；2-ethyl-6-pyrrolidin-1-ylbenzo[de]isoquinoline-1,3-dione
• 化学式: C₁₈H₁₈N₂O₂
• 分子量: 294.353
• InChiKey: WYDHPIUDWDNCDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-溴-1,8-萘二甲酸酐 以 甲苯 为溶剂， 生成 4-N-pyrrolidinyl N'-ethyl 1,8-naphthalimide
  参考文献：
  名称：

  Simple naphthalimide based anion sensors: deprotonation induced colour changes and CO2 fixation

  摘要：

  The 4-amino-1,8-naphthalimide based chemosensors 2, 4 and 6 show striking green-to-purple colour changes due to the deprotonation of the 4-amino moiety on interaction with strongly basic anions such as F-: these colour changes reverse gradually with time due to the fixation of atmospheric CO2 (as HCO3-) yielding 1:1 adducts as demonstrated by X-ray crystallography. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2003.09.148

文献信息

• E3 UBIQUITIN LIGASE AGONISTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE E3 UBIQUITIN LIGASE AGONISTS, RELATED METHODS OF USE
  申请人：FRED HUTCHINSON CANCER RESEARCH CENTER

  公开号：US20210047278A1

  公开（公告）日：2021-02-18

  E3 ubiquitin ligase agonists, pharmaceutical compositions including the E3 ubiquitin ligase agonists, and related methods of use are described.