2,2-Dimethyl-N-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-propionamide

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,2-Dimethyl-N-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-propionamide
• 英文别名: 2,2-dimethyl-N-(4-methyl-6-oxo-1H-pyrimidin-2-yl)propanamide
• 化学式: C₁₀H₁₅N₃O₂
• mdl: MFCD24389440
• 分子量: 209.248
• InChiKey: WDUQNPOSKKTZBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.6
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-Dimethyl-N-(4-methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-propionamide 在 ferric nitrate 作用下， 以 甲醇 为溶剂， 以75%的产率得到2-氨基-4-羟基-6-甲基嘧啶
  参考文献：
  名称：

  2-Pivalamido-3 H -pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO 3 ) 3 in MeOH

  摘要：

  A simple methodology for pivalamide (trimethylacetamide, pivaloylamino) hydrolysis has been discovered using Fe(NO3)(3) in MeOH at room temperature. The pivalamido group of 2-pivilamido-3H-pyrimidin-4-ones or fused 2-pivalamido-3H-pyrimidin-4-ones such as 2-pivilamido-3H-quinazolin-4-ones and 2-pivalamido-3H-pteridines have been hydrolysed under these conditions to afford the corresponding amine. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.123

文献信息

• 2-Pivalamido-3 H -pyrimidin-4-one derivatives: convenient pivalamide hydrolysis using Fe(NO 3 ) 3 in MeOH
  作者：V. Bavetsias、E.A. Henderson、E. McDonald

  DOI：10.1016/j.tetlet.2004.05.123

  日期：2004.7

  A simple methodology for pivalamide (trimethylacetamide, pivaloylamino) hydrolysis has been discovered using Fe(NO3)(3) in MeOH at room temperature. The pivalamido group of 2-pivilamido-3H-pyrimidin-4-ones or fused 2-pivalamido-3H-pyrimidin-4-ones such as 2-pivilamido-3H-quinazolin-4-ones and 2-pivalamido-3H-pteridines have been hydrolysed under these conditions to afford the corresponding amine. (C) 2004 Elsevier Ltd. All rights reserved.