Chembridge 7353529 | 18510-67-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: Chembridge 7353529
• 英文别名: BC11-19-4；2-(4-Chlorphenyl)-benzothiazolo<3,2-a><1,3,5>triazin-1,3-dion；3-(4-chloro-phenyl)-benzo[4,5]thiazolo[3,2-a][1,3,5]triazine-2,4-dione；3-(4-chlorophenyl)-2H-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4(3H)-dione；3-(4-chlorophenyl)-[1,3,5]triazino[2,1-b][1,3]benzothiazole-2,4-dione
• CAS: 18510-67-3
• 化学式: C₁₅H₈ClN₃O₂S
• 分子量: 329.766
• InChiKey: VSCAHUFEOQIMGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-(1,3-苯并噻唑-2-基)乙酰胺 、 对氯苯异氰酸酯 在 吡啶 作用下， 生成 Chembridge 7353529
  参考文献：
  名称：

  Gizycki,U. v.; Oertel,G., Angewandte Chemie, 1968, vol. 80, p. 362 - 363

  摘要：

  DOI：

文献信息

• INHIBITORS OF PHOSPODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATE CORTISOL PRODUCTION
  申请人：TRUSTEES OF BOSTON COLLEGE

  公开号：US20140323503A1

  公开（公告）日：2014-10-30

  The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject.
• MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
  申请人：Merck Patent GmbH

  公开号：US20220310932A1

  公开（公告）日：2022-09-29

  The invention relates to compounds which are suitable for use in electronic devices, and to electronic devices, in particular organic electroluminescent devices, containing said compounds.
• US9173884B2
  申请人：——

  公开号：US9173884B2

  公开（公告）日：2015-11-03
• [EN] INHIBITORS OF PHOSPHODIESTERASES 11 (PDE11) AND METHODS OF USE TO ELEVATE CORTISOL PRODUCTION<br/>[FR] INHIBITEURS DE PHOSPHODIESTÉRASES 11 (PDE11) ET PROCÉDÉS D'UTILISATION POUR AUGMENTER LA PRODUCTION DE CORTISOL
  申请人：TRUSTEES BOSTON COLLEGE

  公开号：WO2013082275A1

  公开（公告）日：2013-06-06

  The present intervention generally relates to compositions comprising a PDE11 inhibitor for increasing cortisol levels in a subject, or for increasing the production of cortisol from adenocortical cells in a subject. Aspects of the invention relate to the use of a PDE11 inhibitor in a method of treatment of low cortisol levels and/or adrenal insufficiency in a subject, or a method of treating a disease or disorders associated with adrenal insufficiency. Aspects of the invention relate to PDE11 inhibitors belonging to compounds of formula (I)-(VI), and their use alone or in combination with long-term corticosteroid treatment to elevate cortisol levels in a subject, and/or to treat adrenal insufficiency. Another aspect relates to kits comprising PDE11 inhibitors for administration to a subject, pharmaceutical compositions comprising compounds of formula (I)-(VI) for use in methods to increase cortisol levels and/or treat adrenal insufficiency, and their use as an adjuvant for treatment of cancer or other disorders such as psychiatric diseases where elevating cortisol levels would be beneficial to the subject.
• [EN] MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES<br/>[FR] MATÉRIAUX POUR DISPOSITIFS ÉLECTROLUMINESCENTS ORGANIQUES<br/>[DE] MATERIALIEN FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN
  申请人：MERCK PATENT GMBH

  公开号：WO2021043703A1

  公开（公告）日：2021-03-11

  Die vorliegende Erfindung betrifft Verbindungen, die sich für die Verwendung in elektronischen Vorrichtungen eignen, sowie elektronische Vorrichtungen, insbesondere organischen Elektrolumineszenzvorrichtungen, enthaltend diese Verbindungen.