9-(5,5-Difluoro-5-Phosphonopentyl)Guanine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
• 英文别名: [5-(2-amino-6-oxo-1H-purin-9-yl)-1,1-difluoropentyl]phosphonic acid
• 化学式: C₁₀H₁₄F₂N₅O₄P
• 分子量: 337.22
• InChiKey: JANQQPWTLXUSCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-amino-6-chloro-9-<5,5-difluoro-5-(diethylphosphono)pentyl>purine 生成 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine
  参考文献：
  名称：

  HALAZY, S.;EHRHARD, A.;DANZIN, C., J. AMER. CHEM. SOC., 113,(1991) N, C. 315-317

  摘要：

  DOI：

文献信息

• Method and reagent for inhibiting the expression of disease related genes
  申请人：RIBOZYME PHARMACEUTICALS, INC.

  公开号：EP1260586A2

  公开（公告）日：2002-11-27

  Enzymatic RNA molecules which cleave ICAM-1 mRNA, IL-5 mRNA, rel A mRNA, TNF-α mRNA, RSV mRNA or RSV genomic RNA, or CML associated mRNA, and use of these molecules for the treatment of pathological conditions related to those mRNA-levels; ribonucleosides or nucleotides modified in 2', 3' or 5', methods for their synthesis, purification and deprotection; vectors containing multiple enzymatic nucleic acids, optionally in chimeric form with tRNAs; method for introducing enzymatic nucleic acids into cells by forming a complex with a second nucleic acid, where the complex is capable of taking an R-loop base-paired structure; method for altering a mutant nucleic acid in vivo by hybridization with an oligonucleotide capable of activating ds RNA deaminase, comprising an enzymatic activity or a chemical mutagen. Further are disclosed trans-cleaving or -ligating hairpin ribozymes lacking a substrate RNA moiety, as well as hammerhead ribozymes having an interconnecting loop between base pairs in stem II.

  裂解 ICAM-1 mRNA、IL-5 mRNA、rel A mRNA、TNF-α mRNA、RSV mRNA 或 RSV 基因组 RNA 或 CML 相关 mRNA 的酶 RNA 分子，以及使用这些分子治疗与这些 mRNA 水平相关的病理状况；核糖核苷或 2'、3'或 5'修饰的核苷酸，其合成、纯化和脱保护的方法；含有多种酶核酸的载体，可选择与 tRNA 的嵌合形式；通过与第二种核酸形成复合物将酶核酸导入细胞的方法，其中复合物能形成 R 环碱基配对结构；通过与能激活 ds RNA 脱氨酶的寡核苷酸杂交改变体内突变核酸的方法，该寡核苷酸包括酶活性或化学诱变剂。此外，还公开了缺乏底物 RNA 分子的反式裂解或ligating 发夹核糖核酶，以及在茎 II 中碱基对之间具有互连环的锤头核糖核酶。
• Method for purifying chemically modified RNA
  申请人：RIBOZYME PHARMACEUTICALS, INC.

  公开号：EP1502950A2

  公开（公告）日：2005-02-02

  Disclosed are processes for deprotecting and/or purifying chemically synthesised RNAs, especially enzymatic nucleic acids or antisense oligonucleotides, having one or more chemical modifications.

  所公开的是对具有一种或多种化学修饰的化学合成 RNA（特别是酶核酸或反义寡核苷酸）进行脱保护和/或纯化的工艺。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Phosphonoalkylpurine derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0338887B1

  公开（公告）日：1993-12-08
• METHOD AND REAGENT FOR INHIBITING THE EXPRESSION OF DISEASE RELATED GENES
  申请人：RIBOZYME PHARMACEUTICALS, INC.

  公开号：EP0746614A1

  公开（公告）日：1996-12-11