2-丙-2-烯基-3a,4,5,6,7,7alpha-六氢异吲哚-1,3-二酮 | 68260-70-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 中文名称: 2-丙-2-烯基-3a,4,5,6,7,7alpha-六氢异吲哚-1,3-二酮
• 英文名称: 2-allylhexahydro-2H-isoindole-1,3-dione
• 英文别名: N-allyl-tetrahydrophthalimide；2-allylhexahydro-1,3-isoindoledione；2-Prop-2-enyl-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
• CAS: 68260-70-8
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: HOADZLUEDQUBQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-丙-2-烯基-3a,4,5,6,7,7alpha-六氢异吲哚-1,3-二酮 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以65%的产率得到2-allyl-3-hydroxyoctahydroisoindol-1-one
  参考文献：
  名称：

  Synthesis of 3-substituted N-allylisoindolinone derivatives by the acetate method

  摘要：

  A series of N-allylisoindolinone derivatives were prepared by a novel sequential reaction of 2-allyl-3-oxoisoindolin-1-yl acetate with C-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate. The nucleophiles included arenes, alkenes, and active methylene to give 3-substituted N-allylisoindolinone products. This method was applied to synthesize cyclohexane-fused indolizidine alkaloid mimics using Grubbs' catalyst..

  DOI：

  10.1007/s00706-013-1127-z

文献信息

• JP2023/52031
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis of 3-substituted N-allylisoindolinone derivatives by the acetate method
  作者：Ibrahim A. I. Ali

  DOI：10.1007/s00706-013-1127-z

  日期：2014.5

  A series of N-allylisoindolinone derivatives were prepared by a novel sequential reaction of 2-allyl-3-oxoisoindolin-1-yl acetate with C-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate. The nucleophiles included arenes, alkenes, and active methylene to give 3-substituted N-allylisoindolinone products. This method was applied to synthesize cyclohexane-fused indolizidine alkaloid mimics using Grubbs' catalyst..