[1-11C]phenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [1-11C]phenol
• 英文别名: (111C)cyclohexatrienol
• 化学式: C₆H₆O
• 分子量: 93.102
• InChiKey: ISWSIDIOOBJBQZ-KWCOIAHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  [1-11C]aniline 在 氢溴酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 0.08h， 生成 [1-11C]phenol
  参考文献：
  名称：

  Synthesis of [1-11C]phenol

  摘要：

  The synthesis of no-carrier-added [1-C-11]phenol (3) which is a further important aromatic C-11 unit for potential PET radiotracers is described for the first time. [1-C-11]Aniline (1) was diazotized and the [1-C-11]benzenediazonium bromide (2) formed was concentrated in situ to give 3. Before diazotization, 1 had to be purified twice by means of an adsorber resin and a cation exchange resin. Starting from the purified 1, 3 was obtained in a radiochemical purity of about 79 % within 10 min. Related to crude 1 from the one-pot process, the reproducible radiochemical yield of 3 was about 16 % (decay-corrected). C-13/C-11 Go-labelling experiments were carried out in order to confirm the identity of 3 and the position of the label.

  DOI：

  10.1002/(sici)1099-1344(200005)43:6<557::aid-jlcr341>3.0.co;2-u

文献信息

• Synthesis of [1-11C]phenol
  作者：P. M�ding、J. Steinbach

  DOI：10.1002/(sici)1099-1344(200005)43:6<557::aid-jlcr341>3.0.co;2-u

  日期：2000.5

  The synthesis of no-carrier-added [1-C-11]phenol (3) which is a further important aromatic C-11 unit for potential PET radiotracers is described for the first time. [1-C-11]Aniline (1) was diazotized and the [1-C-11]benzenediazonium bromide (2) formed was concentrated in situ to give 3. Before diazotization, 1 had to be purified twice by means of an adsorber resin and a cation exchange resin. Starting from the purified 1, 3 was obtained in a radiochemical purity of about 79 % within 10 min. Related to crude 1 from the one-pot process, the reproducible radiochemical yield of 3 was about 16 % (decay-corrected). C-13/C-11 Go-labelling experiments were carried out in order to confirm the identity of 3 and the position of the label.