哌嗪(六水) | 142-63-2

• 物质功能分类: 医药中间体 - 杂环化合物 - 哌嗪类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 哌嗪(六水)
• 中文别名: 哌嗪六水合物；哌嗪(六水合)；二乙烯二胺(六水)；哌嗪,六水合物；六水哌嗪；哌嗪,六水
• 英文名称: Piperazine hexahydrate
• 英文别名: piperazine;hexahydrate
• CAS: 142-63-2
• 化学式: C4H22N2O6
• 分子量: 194.23
• InChiKey: AVRVZRUEXIEGMP-UHFFFAOYSA-N

物化性质

• 熔点：
  42-44 °C(lit.)
• 沸点：
  145-156 °C(lit.)
• 密度：
  1.2903 (rough estimate)
• 闪点：
  190 °F
• 暴露限值：
  ACGIH: TWA 0.03 ppm

计算性质

• 辛醇/水分配系数(LogP)：
  -5.77
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.1
• 氢给体数：
  8
• 氢受体数：
  8

安全信息

• TSCA：
  Yes
• 危险等级：
  8
• 危险品标志：
  C
• 安全说明：
  S22,S26,S36/37/39,S45,S61
• 危险类别码：
  R34,R42/43,R52/53
• WGK Germany：
  1
• 海关编码：
  2933599090
• 危险品运输编号：
  UN 2579 8/PG 3
• RTECS号：
  TM0850000
• 包装等级：
  III
• 危险类别：
  8

制备方法与用途

简介

哌嗪(六水)是一种杂环有机物，常用于医药和有机化合物的合成。

用途

它主要用于合成硝呋哌酮（Nifurpipone）、利福平及乙酰哌嗪等药物。此外，哌嗪还应用于医药、造船以及塑料工业中。

反应信息

• 作为反应物：
  描述：

  哌嗪(六水) 、 1-溴-3-苯基丙烷 以79%的产率得到
  参考文献：
  名称：

  ZIKOLOVA S., TR. N.-I. XIM.-FARM. IN-T, 1978, 10, 33-46

  摘要：

  DOI：

文献信息

• Piperazinyl derivatives of quinoline carboxylic acids
  申请人：Kyorin Seiyaku Kabushiki Kaisha

  公开号：US04146719A1

  公开（公告）日：1979-03-27

  This invention relates to new compounds of value as antibacterial agent. More particularly, it relates to piperazinyl derivatives of quinoline carboxylic acids, the hydrates, and the acid addition salts thereof.

  本发明涉及一种新的化合物，用作抗菌剂的价值。更具体地说，它涉及喹啉羧酸的哌嗪衍生物，其水合物和酸加成盐。
• Salts of novel p-dihydroxybenezene disulfonic acids
  申请人：Laboratorios Del Dr. Esteve SA

  公开号：US03947448A1

  公开（公告）日：1976-03-30

  Salts of p-dihydroxy benzene disulfonic acids having the general formula: ##SPC1## Wherein B is an alkali metal or an equivalent of an alkaline-earth metal, or BH is the cation of ammonia or a nitrogen containing basic organic compound, are useful for reducing the average bleeding time and for combating capillary fragility.

  具有以下通式的对二羟基苯二磺酸盐：##SPC1##其中B是碱金属或碱土金属的等价物，或BH是氨或含氮的有机碱性化合物的阳离子，可用于减少平均出血时间和对抗毛细血管脆性。
• Use of .alpha..sub.1C specific compounds to treat benign prostatic
  申请人：Synaptic Pharmaceutical Corporation

  公开号：US05403847A1

  公开（公告）日：1995-04-04

  A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human .alpha..sub.1C adrenergic receptor with a binding affinity greater than ten-fold higher than the binding affinity with which the compound binds to a human .alpha..sub.1A adrenergic receptor, a human .alpha..sub.1B adrenergic receptor, and a human histamine H.sub.1 receptor, and, binds to a human .alpha..sub.2 adrenergic receptor with a binding affinity which is greater than ten-fold lower than the binding affinity with which the compound binds to such .alpha..sub.1C adrenergic receptor. Compounds meeting these criteria are provided.

  一种治疗良性前列腺增生症的方法，包括向受试者施用一种治疗有效量的化合物，该化合物与人类α1C肾上腺素能受体结合的结合亲和力比其与人类α1A肾上腺素能受体、人类α1B肾上腺素能受体和人类组胺H1受体结合的结合亲和力高出十倍以上，并且与人类α2肾上腺素能受体的结合亲和力比其与此类α1C肾上腺素能受体结合的结合亲和力低出十倍以上。提供了符合这些标准的化合物。
• Antibacterial pharmaceutical compositions and processes for preparation
  申请人：Dainippon Pharmaceutical Co., Ltd.

  公开号：US03962443A1

  公开（公告）日：1976-06-08

  This invention provides compounds of the following formula ##SPC1## Wherein R.sub.1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a hydroxyalkyl group having 2 to 4 carbon atoms, a benzyl group, a benzyl group subsituted by methoxy, a phenyl group, a propargyl group or an acyl group; R.sub.2 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkyl group having 2 to 4 carbon atoms substituted by hydroxy or halogen, a vinyl group, an allyl group, or a benzyl group R.sub.3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; And salts thereof, and processes for preparing them. Some of the compounds have antibacterial activities.

  本发明提供以下式子的化合物：##SPC1## 其中，R1是氢原子、具有1至4个碳原子的烷基、具有2至4个碳原子的羟基烷基、苄基、被甲氧基取代的苄基、苯基、丙炔基或酰基；R2是氢原子、具有1至4个碳原子的烷基、被羟基或卤素取代的具有2至4个碳原子的烷基、乙烯基、烯丙基或苄基；R3是氢原子或具有1至6个碳原子的烷基；以及其盐和制备它们的方法。其中一些化合物具有抗菌活性。
• 2,4,5,6-Tetrasubstituted pyrimidines and salts thereof
  申请人：Boehringer Ingelheim GmbH

  公开号：US03975384A1

  公开（公告）日：1976-08-17

  Compounds of the formula ##SPC1## Wherein R.sub.1 is alkoxy of 1 to 3 carbon atoms, morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, or ##EQU1## where A is hydrogen, alkanoyl of 1 to 4 carbon atoms, alkenoyl of 2 to 4 carbon atoms, methoxy-(alkanoyl of 1 to 4 carbon atoms), carboxyl-(alkanoyl of 1 to 4 carbon atoms), acetyl-(alkanoyl of 1 to 4 carbon atoms), methoxy-(alkenoyl of 2 to 4 carbon atoms), carboxyl-(alkenoyl of 2 to 4 carbon atoms), acetyl-(alkenoyl of 2 to 4 carbon atoms), aminocarbonyl, mono(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, di-(alkyl of 1 to 4 carbon atoms)-aminocarbonyl, methoxymethylaminocarbonyl, pyridinoyl, salicyloyl, furanoyl, or (alkyl of 1 to 3 carbon atoms)-sulfonyl, R.sub.2 is morpholino, thiomorpholino, 1-oxido-thiomorpholino, 1,1-dioxido-thiomorpholino, piperazino or N'-[acetyl-(alkanoyl of 1 to 3 arbon atoms)]-piperazino, R.sub.3 is hydrogen, chlorine, bromine, nitro, cyano, formyl, acetyl or carbalkoxy of 2 to 4 carbon atoms, and R.sub.4 is hydrogen, chlorine, bromine, cyano, carbalkoxy of 2 to 4 carbon atoms, alkyl of 1 to 6 carbon atoms, mono(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, di(carbalkoxy of 2 to 4 carbon atoms)-alkyl of 1 to 6 carbon atoms, hydroxyl, allyloxy, alkoxy of 1 to 6 carbon atoms, mercapto, allylmercapto, (alkyl of 1 to 6 carbon atoms)-mercapto, 1-oxidothiomorpholino, or --NHB where B is hydrogen, alkyl of 1 to 3 carbon atoms, cyclohexyl, phenyl, chloro-phenyl, carboxy-phenyl, carbomethoxy-phenyl or pyridyl, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as antithrombotics.

  化合物的公式为##SPC1##其中R.sub.1是1到3个碳原子的烷氧基，吗啡环，硫代吗啡环，1-氧代硫代吗啡环，1,1-二氧代硫代吗啡环或##EQU1##其中A是氢，1到4个碳原子的烷酰基，2到4个碳原子的烯酰基，甲氧基-(1到4个碳原子的烷酰基)，羧基-(1到4个碳原子的烷酰基)，乙酰基-(1到4个碳原子的烷酰基)，甲氧基-(2到4个碳原子的烯酰基)，羧基-(2到4个碳原子的烯酰基)，乙酰基-(2到4个碳原子的烯酰基)，氨基羰基，单(1到4个碳原子的烷基)-氨基羰基，双(1到4个碳原子的烷基)-氨基羰基，甲氧甲基氨基羰基，吡啶酰基，水杨酰基，呋喃酰基或(1到3个碳原子的烷基)-磺酰基，R.sub.2是吗啡环，硫代吗啡环，1-氧代硫代吗啡环，1,1-二氧代硫代吗啡环，哌嗪或N'-[乙酰-(1到3个碳原子的烷酰基)]-哌嗪，R.sub.3是氢，氯，溴，硝基，氰基，甲酰基，乙酰基或2到4个碳原子的羧基烷氧基，R.sub.4是氢，氯，溴，氰基，2到4个碳原子的羧基烷氧基，1到6个碳原子的烷基，单(2到4个碳原子的羧基烷氧基)-1到6个碳原子的烷基，双(2到4个碳原子的羧基烷氧基)-1到6个碳原子的烷基，羟基，丙烯氧基，1到6个碳原子的烷氧基，巯基，丙烯基巯基，(1到6个碳原子的烷基)-巯基，1-氧代硫代吗啡环，或--NHB，其中B是氢，1到3个碳原子的烷基，环己基，苯基，氯苯基，羧基苯基，羧甲氧基苯基或吡啶基，以及其无毒、药理学上可接受的酸盐；这些化合物及其盐可用作抗血栓药。