9-(呋喃-2-基甲基)嘌呤-6-胺 | 2296-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 9-(呋喃-2-基甲基)嘌呤-6-胺
• 英文名称: furfuryladenine
• 英文别名: 9-Furfuryl-6-amino-purin；9-Furfuryl-adenin；9-furfuryl-9H-purin-6-ylamine；9-Furfuryladenine；9-(furan-2-ylmethyl)purin-6-amine
• CAS: 2296-08-4
• 化学式: C₁₀H₉N₅O
• 分子量: 215.214
• InChiKey: VQQPYKDHUQQMHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  9-Furfuryl-6-chlor-purin 在 乙醇 、 氨 作用下， 生成 9-(呋喃-2-基甲基)嘌呤-6-胺
  参考文献：
  名称：

  560.激动素和一些相关杂环化合物的合成

  摘要：

  DOI：

  10.1039/jr9580002746

文献信息

• [EN] 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SKIN DISORDERS<br/>[FR] DÉRIVÉS DE 9-(2-OXACYCLOALKYL)-9H-PURINE-2,6-DIAMINE ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES CUTANÉS
  申请人：UNIV PALACKEHO

  公开号：WO2018196893A1

  公开（公告）日：2018-11-01

  The invention relates to N 2 ,N 6 -disubstituted-9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

  该发明涉及N2，N6-二取代-9-(2-氧杂环烷基)-9H-嘌呤-2,6-二胺衍生物及其作为药物和化妆品的用途。本发明的化合物展现出与氧化应激抑制相关的多种生物活性，特别是抗衰老、抗炎和抗神经退行性生物活性。该发明还涉及含有这些衍生物作为活性剂的化妆品和药用组合物。
• [EN] METHOD AND PREPARATION FOR REDUCING IRRITATION AND/OR INFLAMMATORY REACTION IN HUMAN SKIN<br/>[FR] PROCEDE ET PREPARATION REDUISANT LES IRRITATIONS ET/OU LES REACTIONS INFLAMMATOIRES DE LA PEAU CHEZ L'HOMME
  申请人：PCR TECHNOLOGY HOLDINGS LC

  公开号：WO2005079775A1

  公开（公告）日：2005-09-01

  A method for reducing an occurrence of irritation and/or inflammatory reaction in human skin includes applying a topical preparation to the skin. The preparation and/or inflammatory reaction in human skin. The agent includes idebenone or a derivative of idebenone.

  一种减少人类皮肤刺激和/或炎症反应发生的方法，包括将局部制剂应用于皮肤。该制剂包括idebenone或idebenone的衍生物，以减少皮肤刺激和/或炎症反应的发生。
• NOVEL PEPTIDES, USE THEREOF IN COSMETIC AND COSMECEUTIC APPLICATIONS, AND COMPOSITIONS COMPRISING SAME
  申请人：Hocquaux Michel

  公开号：US20100310484A1

  公开（公告）日：2010-12-09

  A peptide of formula I (SEQ ID NO: 1): Lip-A-Gly-His-B-R (I) wherein: Lip is a lipoyl residue of R or S configuration; A is absent or is a lysine residue of configuration L or D; GIy is a glycine residue; His is a histidine residue of configuration L or D; B is a lysine residue of configuration L or D, or a lysine residue of configuration L or D in which the NH2 group of the side chain comprises a modification, wherein said modification is (i) a replacement with a hydrogen or (ii) a modification with a protecting group selected from the group consisting of acetyl, benzoyl, tosyl, sulfonyl benzene, benzyloxycarbonyle and palmitoyl; wherein R is O(Z) or N(Z′)(Z′), and wherein Z, Z′ and Z′ are independently of each other a hydrogen or a protecting group selected from the group consisting of methyl, ethyl, propyl, phenyl, hexyl, decyl and hexadecyl, or a racemate, an enantiomer or a diastereomer thereof, or a mixture thereof, or a salt thereof. A peptide of formula II (SEQ ID NO: 2): Lip-A-His-B-C-Trp-R (II) wherein: Lip is a lipoyl residue of configuration R or S; His is a histidine residue of configuration L; Trp is a tryptophane residue of configuration L; A is absent, is an amino acid residue of configuration L or D selected from the group consisting of a lysine residue, an alanine residue, a glutamic acid residue and a glycine residue, or is a spacer of formula: NH—(CH2)n-CO— wherein n is an integer comprised between 2 and 14; B is an aromatic amino acid residue of configuration D selected from the group consisting of a phenylalanine residue, a homophenylalanine residue, a tryptophane residue, a β-(1-Naphthyl)-alanine residue, a β-(2-Naphthyl)-alanine residue and a phenylglycine residue; C is a basic amino acid residue of configuration L selected from the group consisting of an arginine residue, a lysine residue, an ornithine residue and a homoarginine residue; wherein R is O(Z) or N(Z′)(Z′),

  序列编号为1的肽类分子式为I：Lip-A-Gly-His-B-R，其中：Lip是R或S构型的脂肪酰残基；A不存在或是L或D构型的赖氨酸残基；Gly是甘氨酸残基；His是L或D构型的组氨酸残基；B是L或D构型的赖氨酸残基，或是其侧链的NH2基团经修饰后的赖氨酸残基，该修饰是(i)用氢原子替换或(ii)用保护基选自乙酰基、苯甲酰基、托磺基苯、苄氧羰基和棕榈酰基的保护基进行修饰；其中R是O(Z)或N(Z′)(Z′)，Z、Z′和Z′独立地选自氢原子或选自甲基、乙基、丙基、苯基、己基、癸基和十六烷基的保护基，或是它们的外消旋体、对映体或二对映异构体的混合物，或是其盐。 序列编号为2的肽类分子式为II：Lip-A-His-B-C-Trp-R，其中：Lip是R或S构型的脂肪酰残基；His是L构型的组氨酸残基；Trp是L构型的色氨酸残基；A不存在，是选自L或D构型的氨基酸残基的赖氨酸残基、丙氨酸残基、谷氨酸残基和甘氨酸残基，或是分子式为NH—(CH2)n-CO—，其中n为2至14之间的整数的间隔物；B是D构型的芳香族氨基酸残基，选自苯丙氨酸残基、同型苯丙氨酸残基、色氨酸残基、β-(1-萘基)-丙氨酸残基、β-(2-萘基)-丙氨酸残基和苯基甘氨酸残基；C是L构型的碱性氨基酸残基，选自精氨酸残基、赖氨酸残基、鸟氨酸残基和同型精氨酸残基；其中R是O(Z)或N(Z′)(Z′)。
• Composition for the treatment of cut tulip flowers
  申请人：Instituut voor Agrotechnologisch Onderzoek (ATO-DLO)

  公开号：EP0993776A1

  公开（公告）日：2000-04-19

  The invention provides a floral composition suitable for preventing rapid stem elongation and prolonging vase life of cut tulips, comprising (A) an ethylene-releasing compound or ethylene precursor, (B) a gibberellin, and (C) a cytokinin, the molar ratio (A) : (B) being between 0.1 and 2, the molar ratio (A) : (C) being between 0.3 and 5, and the molar ratio (B) : (C) being between 0.5 and 10, and optionally (D) calcium chloride, with a molar ratio (A) : (D) between 0.002 and 0.03.

  本发明提供了一种适用于防止切花郁金香茎干快速伸长并延长其花瓶寿命的花卉组合物，该组合物包括(A)乙烯释放化合物或乙烯前体，(B)赤霉素和(C)细胞分裂素，摩尔比(A)∶(B)在0. 1和2之间，摩尔比(A)∶(C)在0.3和5之间，摩尔比(B)∶(C)在0.5和10之间，可选(D)氯化钙，摩尔比(A)∶(D)在0.002和0.03之间。
• NANOPARTICULATE SYSTEMS PREPARED FROM ANIONIC POLYMERS
  申请人：Universidade De Santiago De Compostela

  公开号：EP2366386A1

  公开（公告）日：2011-09-21

  The present invention relates to a system for administering active ingredients comprising nanoparticles having an average size of less than 1 micrometer in turn comprising: (a) at least one anionic polymer; (b) a cationic cross-linking agent; and optionally (c) a cationic polymer; characterized in that the nanoparticles are cross-linked by means of electrostatic type interactions. Additionally, the invention relates to pharmaceutical, cosmetic, personal hygiene and nutritional compositions comprising said nanoparticle system, as well as to methods for the preparation and uses thereof.

  本发明涉及一种用于施用活性成分的系统，该系统由平均粒径小于 1 微米的纳米微粒组成，纳米微粒依次包括：(a) 至少一种阴离子聚合物；(b) 一种阳离子交联剂；以及可选的 (c) 一种阳离子聚合物；其特征在于纳米微粒通过静电型相互作用交联。此外，本发明还涉及包含上述纳米颗粒系统的药物、化妆品、个人卫生和营养组合物，以及其制备和使用方法。