3-Amino-3-thiophen-2-yl-propan-1-ol | 683220-39-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Amino-3-thiophen-2-yl-propan-1-ol
• 英文别名: 3-Amino-3-(thiophen-2-yl)propan-1-ol；3-amino-3-thiophen-2-ylpropan-1-ol
• CAS: 683220-39-5
• 化学式: C₇H₁₁NOS
• mdl: MFCD03412630
• 分子量: 157.236
• InChiKey: OQMOVOFGDQVPQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  74.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-Amino-3-thiophen-2-yl-propan-1-ol 在 偶氮二甲酸二叔丁酯 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

  摘要：

  SAR studies of 1, 3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.038
• 作为产物：
  描述：

  3-氨基-3-(2-噻吩基)丙酸 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 3-Amino-3-thiophen-2-yl-propan-1-ol
  参考文献：
  名称：

  Structure–activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists

  摘要：

  SAR studies of 1, 3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.038

文献信息

• Site‐Specific C(sp³)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions
  作者：Rong Zhao、Kang Fu、Yuanding Fang、Jia Zhou、Lei Shi

  DOI：10.1002/anie.202008806

  日期：2020.11.9

  utilization of N‐centered radicals to synthesize nitrogen‐containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C−N bonds. However, the generation and control of N‐centered radicals remain particularly challenging. We report a tethering strategy using SOMO‐HOMO‐converted distonic radical anions for the site‐specific

  由于以N为中心的自由基具有强大的反应活性和随之而来的C-N键结构，因此利用N中心自由基合成含氮化合物已引起了广泛的关注。但是，以N为中心的自由基的产生和控制仍然特别具有挑战性。我们报告了在非共价相互作用的帮助下，使用SOMO-HOMO转化的二歧自由基阴离子进行亚胺和am定点胺化的束缚策略。该反应具有显着广泛的底物范围，并且还可以实现生物活性分子的后期功能化。此外，通过动力学研究，拉曼光谱，电子顺磁共振光谱和密度泛函理论计算，对反应机理进行了深入研究，
• Process for the prepation of 3-hydroxy-(2-thienyl)propanamines
  申请人：Hems William

  公开号：US20050272930A1

  公开（公告）日：2005-12-08

  The present invention relates to a process for the preparation of compounds of the general formula (I) by catalytic enantioselective hydrogenation of the corresponding ketones. There are used inter alia ruthenium catalysts with chiral diamines and chiral biphosphines as ligands.

  本发明涉及一种通过对应酮的催化不对称氢化制备通式（I）化合物的方法。其中使用了具有手性二胺和手性双膦配体的钌催化剂。
• 3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands
  申请人：Taveras Arthur G.

  公开号：US20110213029A1

  公开（公告）日：2011-09-01

  There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

  公开了以下式的化合物，或其药学上可接受的盐或溶剂，它们可用于治疗由趋化因子介导的疾病，如急性和慢性炎症性疾病和癌症。
• [EN] PROCESS FOR THE PREPARATION OF 3-HYDROXY-(2-THIENYL)PROPANAMINES<br/>[FR] PROCEDE DE PREPARATION DE 3-HYDROXY-(2-THIENYL)PROPANAMINES
  申请人：DEGUSSA

  公开号：WO2004011452A1

  公开（公告）日：2004-02-05

  The present invention relates to a process for the preparation of compounds of the general formula (I) by catalytic enantioselective hydrogenation of the corresponding ketones. There are used inter alia ruthenium catalysts with chiral diamines and chiral biphosphines as ligands.

  本发明涉及一种通过催化不对称氢化相应的酮类化合物制备通式（I）化合物的方法。使用的催化剂包括带手性二胺和手性双膦配体的钌催化剂等。
• AMPHOTERIC DISSOCIATION ION EXCHANGE MEDIUM, APPLICATION METHOD, AND SEPARATION CAPACITY CALIBRATION METHOD
  申请人：Chongqing Bolanying (BLY) Biotechnology Co., Ltd., China

  公开号：EP3546066A1

  公开（公告）日：2019-10-02

  An amphoteric dissociation ion exchange medium. The surface of the amphoteric dissociation ion exchange medium is an amphoteric dissociation covalent modification layer. When an environmental pH value is lower than an isoelectric point of the amphoteric dissociation covalent modification layer, the surface net charge of the amphoteric dissociation covalent modification layer is positive, so that the amphoteric dissociation covalent modification layer has the property of anion exchanger; when the environmental pH value is higher than isoelectric point of the amphoteric dissociation covalent modification layer, the surface net charge of the amphoteric dissociation covalent modification layer is negative, so that the amphoteric dissociation covalent modification layer has the property of cation exchanger. The separation medium respectively has the property of the anion exchanger and the cation exchanger at the two sides of the isoelectric point, so that by adjusting the pH value of an eluant, the net charges on the surface of the separation medium and a target substance are same, so that a target substance can be released due to electrostatic repulsion, the elution effect is enhanced and subsequent problems due to application of high-concentration inorganic ions are avoided. The novel ion exchange medium has a high separation capacity, a high elution effect on the absorbed ions in a moderate condition, can accurately calibrate a separation capacity, has low non-specific adsorption to hydrophobic small molecules, and has a high regeneration effect in the moderate condition.

  两性解离离子交换介质。两性解离离子交换介质的表面是两性解离共价修饰层。当环境 pH 值低于两性离解共价修饰层的等电点时，两性离解共价修饰层的表面净电荷为正，因此两性离解共价修饰层具有阴离子交换特性；当环境 pH 值高于两性解离共价改性层的等电点时，两性解离共价改性层的表面净电荷为负，使两性解离共价改性层具有阳离子交换特性。分离介质在等电点两侧分别具有阴离子交换剂和阳离子交换剂的性质，因此通过调节洗脱剂的 pH 值，分离介质表面的净电荷与目标物质的净电荷相同，这样目标物质就能因静电排斥而释放出来，洗脱效果增强，避免了后续因应用高浓度无机离子而产生的问题。新型离子交换介质具有高分离能力，在中等条件下对吸收的离子具有高洗脱效果，可准确校准分离能力，对疏水小分子的非特异性吸附低，在中等条件下具有高再生效果。