(2-bibenzyl-4-yloxy-ethyl)-dimethyl-amine | 101781-36-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (2-bibenzyl-4-yloxy-ethyl)-dimethyl-amine
• 英文别名: (2-Bibenzyl-4-yloxy-aethyl)-dimethyl-amin；4-(2-dimethylaminoethoxy)bibenzyl；N,N-dimethyl-2-[4-(2-phenylethyl)phenoxy]ethanamine
• CAS: 101781-36-6
• 化学式: C₁₈H₂₃NO
• 分子量: 269.387
• InChiKey: MKGYVJCXXURPOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-bibenzyl-4-yloxy-ethyl)-dimethyl-amine 、 碘甲烷 以 二氯甲烷 为溶剂， 生成 (2-bibenzyl-4-yloxy-ethyl)-trimethyl-ammonium; iodide
  参考文献：
  名称：

  Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

  摘要：

  Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha 7 nACh receptors were investigated due to its close structural similarity to a known alpha 7 antagonist. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.080
• 作为产物：
  描述：

  Dimethyl-{2-[4-((E)-styryl)-phenoxy]-ethyl}-amine; hydrochloride 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 (2-bibenzyl-4-yloxy-ethyl)-dimethyl-amine
  参考文献：
  名称：

  Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

  摘要：

  Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha 7 nACh receptors were investigated due to its close structural similarity to a known alpha 7 antagonist. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.05.080

文献信息

• (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0001759A1

  公开（公告）日：1979-05-16

  (Omega-aminoalkoxy)bibenzyls of the general formula processes for their preparation and pharmaceutical compositions containing these substances are disclosed. The (omega-aminoalkoxy)bibenzyls are useful as pharmaceuticai agents, particularly as inhibitors of platelet aggregation

  (公开了通式中的（欧米伽-氨基烷氧基）联苄基化合物的制备工艺和含有这些物质的药物组合物。 这些（欧米伽-氨基烷氧基）联苄基化合物可用作药剂，特别是血小板聚集抑制剂。
• Cavallini; Massarani, Farmaco, Edizione Scientifica, 1954, vol. 9, p. 405,411
  作者：Cavallini、Massarani

  DOI：——

  日期：——
• US4220603A
  申请人：——

  公开号：US4220603A

  公开（公告）日：1980-09-02
• US4323568A
  申请人：——

  公开号：US4323568A

  公开（公告）日：1982-04-06
• Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors
  作者：Hanan M. Ragab、Jin Sung Kim、Małgorzata Dukat、Hernán Navarro、Richard A. Glennon

  DOI：10.1016/j.bmcl.2006.05.080

  日期：2006.8

  Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha 7 nACh receptors were investigated due to its close structural similarity to a known alpha 7 antagonist. (c) 2006 Elsevier Ltd. All rights reserved.