2-Octylamino-aethanthiol | 5891-05-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Octylamino-aethanthiol
• 英文别名: 2-(Octylamino)ethanethiol
• CAS: 5891-05-4
• 化学式: C₁₀H₂₃NS
• mdl: MFCD20542347
• 分子量: 189.365
• InChiKey: LFOQSNPZUHPCHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  13
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-dithiane 1,1-dioxide 、 2-Octylamino-aethanthiol 以 乙醇 为溶剂， 生成 4-<2-n-Octylamino-aethyl-dithio>-butansulfinsaeure
  参考文献：
  名称：

  Organic disulfides and related substances. XXVII. Reactions and synthetic utility of cyclic disulfides, dioxides, and tetroxides

  摘要：

  DOI：

  10.1021/jo01258a058

文献信息

• 7-Oxabicycloheptane substituted prostaglandin analogs
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0164987A2

  公开（公告）日：1985-12-18

  7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula wherein R is hydrogen, lower alkyl or alkali metal, R1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is 0, S or NH, A is -CH=CH- or -(CH2)2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.

  7-氧杂双环庚烷取代的硫代前列腺素类似物具有结构式，其中R为氢、低级烷基或碱金属，R1为低级烷基、芳烷基、芳基、环烷基或环烷基烷基，X为0、S或NH，A为-CH=CH-或-(CH2)2，p为0至4，n为1至4，n'为0至2，q为1至4，m为0至8，并包括其所有立体异构体。 这些化合物是心血管药物，例如用于治疗溶栓疾病；是抗炎药物，例如用于治疗类风湿性关节炎。
• CYSTEAMINE DERIVATIVES AND ANTI-RHEUMATIC AGENT CONTAINING SAME
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0400144A1

  公开（公告）日：1990-12-05

  Cysteamine derivatives represented by general formula (l) (wherein R1 represents a straight-chain or branched alkyl group containing 1 to 6 carbon atoms, R2 represents a hydrogen atom or an n-propyl group, and X represents a group containing a cysteamine moiety (NNS) and represented by general formulae (II), (III), (IV), (V) or (VI) wherein R2 represents a hydrogen atom or a straight-chain or branched alkyle group containing 1 to 10 carbon atoms) are disclosed. These cysteamine derivatives are effective as antirtheumatic agents.

  本研究公开了通式(l)代表的半胱胺衍生物（其中R1代表含有1至6个碳原子的直链或支链烷基，R2代表氢原子或正丙基，X代表含有半胱胺分子（NNS）的基团，通式(II)、(III)、(IV)、(V)或(VI)代表其中R2代表氢原子或含有1至10个碳原子的直链或支链烷基）。这些半胱胺衍生物是有效的抗风湿剂。
• Isoform-selective lysine deacetylase inhibitors
  申请人：WASHINGTON UNIVERSITY

  公开号：US10421778B2

  公开（公告）日：2019-09-24

  Isoform-selective lysine deacetylase inhibitors are described. Inhibitors of the lysine deacetylase enzyme are useful as antitumor drugs and for treating addiction, asthma, cardio-vascular disease, immunosuppression, neurodegenerative diseases, sepsis, sickle-cell disease, uveal melanoma and termination of viral latency, particularly HIV-1 latency.

  介绍了具有同工酶选择性的赖氨酸脱乙酰酶抑制剂。赖氨酸去乙酰化酶抑制剂可用作抗肿瘤药物和治疗成瘾、哮喘、心血管疾病、免疫抑制、神经退行性疾病、败血症、镰状细胞病、葡萄膜黑色素瘤和终止病毒潜伏期，特别是 HIV-1 潜伏期。
• N-Substituted derivatives of 2-aminoethanethiol and 2-hydrazinoethanethiol
  作者：Roger D. Westland、Joyce L. Holmes、Billie Green、John R. Dice

  DOI：10.1021/jm00310a028

  日期：1968.7
• 1-Alkyl-1-(2-mercaptoethyl)quanidines and the corresponding thioureas, disulfides, and thiosulfates and thiosulfates and antibacterial agents
  作者：Roger D. Westland、Eva R. Karger、Billie Green、John R. Dice

  DOI：10.1021/jm00307a018

  日期：1968.1