AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE
申请人:Astra Aktiebolag
公开号:EP0983268A1
公开(公告)日:2000-03-08
US6489322B1
申请人:——
公开号:US6489322B1
公开(公告)日:2002-12-03
[EN] AMIDINE DERIVATIVES AS INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] DERIVES D'AMIDINE UTILISES COMME INHIBITEURS DE MONOXYDE D'AZOTE SYNTHASE
申请人:ASTRA AKTIEBOLAG
公开号:WO1998050382A1
公开(公告)日:1998-11-12
(EN) There are provided novel compounds of formula (I) wherein R1 represents a 2-thienyl or 3-thienyl ring and R2 represents hydrogen or C 1 to 4 alkyl and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are selective inhibitors of the neuronal isoform of nitric oxide synthase.(FR) L'invention concerne de nouveaux composés de la formule (I) où R1 représente un noyau 2-thiényl ou 3-thiényl et R2 représente de l'hydrogène ou alkyle C1-4. L'invention concerne également leurs isomères optiques, racémates et sels pharmaceutiquement tolérables, des procédés de préparation correspondants, des compositions les contenant et leur utilisation en thérapie. Les composés sont des inhibiteurs sélectifs de l'isoforme neuronal de monoxyde d'azote synthase.
Amidine derivatives as inhibitors of nitric oxide synthase
申请人:AstraZeneca AB
公开号:US06489322B1
公开(公告)日:2002-12-03
There are provided novel compounds of formula (I)
wherein R1 represents a 2-thienyl or 3-thienyl ring and R2 represents hydrogen or C 1 to 4 alkyl and optical isomers and racemates thereof and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are selective inhibitors of the neuronal isoform of nitric oxide synthase.