(R)-3-(adenin-9-yl)-2-hydroxypropanoic acid | 69895-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (R)-3-(adenin-9-yl)-2-hydroxypropanoic acid
• 英文别名: (R)-3-Adenin-9-yl-lactic acid；3-(6-amino-purin-9-yl)-2-hydroxy-propionic acid；(2R)-3-(6-aminopurin-9-yl)-2-hydroxypropanoic acid
• CAS: 69895-64-3
• 化学式: C₈H₉N₅O₃
• 分子量: 223.191
• InChiKey: UHOFECKRSHSYNE-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (R)-3-(adenin-9-yl)-2-oxy-((R,S)-1-methoxy-1-carboxy)propanoic acid 在 Dowex 50 (H⁺) 作用下， 反应 12.0h， 以95%的产率得到(R)-3-(adenin-9-yl)-2-hydroxypropanoic acid
  参考文献：
  名称：

  合成光学活性烷基化腺嘌呤衍生物的新方法。

  摘要：

  提出了一种新的手性无环核苷和核苷酸类似物的合成方法，从d（-）-或l（+）-核糖开始。评估了合成化合物对痘病毒家族的抗病毒特性。

  DOI：

  10.1016/j.bmcl.2003.12.107

文献信息

• Prodrug derivatives of acids using alcohols with homotopic hydroxy groups and methods for their preparation and use
  申请人：deLong A. Mitchell

  公开号：US20070254920A1

  公开（公告）日：2007-11-01

  This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and R b is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.

  这项发明涉及新型同位素前药、药物以及其制备、测试和使用方法。在一个实施例中，同位素前药具有一般公式 其中 是包含羧酸官能团的生物活性基团，而 R b 是通过羧酸官能团与生物活性基团形成酯键的同位对称醇，以及其光学异构体、对映异构体、药用可接受盐、生物水解酰胺、酯、亚酰胺及其组合物。
• Composition and use of substances for stabilising amino acids containing sulphur
  申请人：——

  公开号：US20040138169A1

  公开（公告）日：2004-07-15

  The invention relates to a composition for the stabilization of sulphur-containing amino acids and/or for the inhibition of the continuous formation of sulphur-containing amino acids in withdrawn blood, to the use of suitable substances and compositions therefor as well as optionally for the determination of sulphur-containing amino acids in blood, to a process for these purposes, as well as to a blood collecting device applied appropriately to these processes.

  本发明涉及一种用于稳定血液中含硫氨基酸和/或抑制血液中含硫氨基酸持续形成的组合物，涉及合适物质及其组合物的使用，以及用于测定血液中含硫氨基酸的选择，涉及用于上述目的的工艺，以及适用于上述工艺的采血装置。
• ZUSAMMENSETZUNG UND VERWENDUNG VON SUBSTANZEN ZUR STABILISIERUNG VON SCHWEFELHALTIGEN AMINOSÄUREN UND/ODER ZUR HEMMUNG DER FORTLAUFENDEN BILDUNG VON SCHWEFELHATIGEN AMINOSÄUREN IN ENTNOMMENEM BLUT
  申请人：WIELAND, Heinrich

  公开号：EP1392375B1

  公开（公告）日：2008-09-10
• BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE
  申请人：President and Fellows of Harvard College

  公开号：EP2513298A2

  公开（公告）日：2012-10-24
• PRODRUG DERIVATIVES OF ACIDS USING ALCOHOLS WITH HOMOTOPIC HYDROXY GROUPS AND METHODS FOR THEIR PREPARATION AND USE
  申请人：deLong Mitchell A.

  公开号：US20100228015A1

  公开（公告）日：2010-09-09

  This invention relates to novel homotopic prodrugs and medicaments and methods for their preparation, testing and use. In one embodiment, the homotopic prodrug has the general formula wherein is a biologically-active moiety comprising a carboxylic acid functional group, and R b is a homotopically-symmetrical alcohol bonded to the biologically-active moiety through the carboxylic acid functional group to form an ester linkage, as well as optical isomers, enantiomers, pharmaceutically acceptable salts, biohydrolyzable amides, esters, and imides thereof and combinations thereof.