N,N'-dicyclohexylphosphenimidous amide | 1310414-22-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-dicyclohexylphosphenimidous amide
• CAS: 1310414-22-2
• 化学式: C₁₂H₂₃N₂P
• 分子量: 226.302
• InChiKey: MARCBGUFTLEJSJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.29
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.39
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  N,N'-dicyclohexylphosphenimidous amide 、 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid 以 甲苯 为溶剂， 反应 1.0h， 以68%的产率得到N-cyclohexyl-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramide
  参考文献：
  名称：

  Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides

  摘要：

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

  DOI：

  10.1080/00397911.2010.497594
• 作为产物：
  描述：

  环己胺 在 三氯化磷 作用下， 以 甲苯 为溶剂， 生成 N,N'-dicyclohexylphosphenimidous amide
  参考文献：
  名称：

  Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides

  摘要：

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

  DOI：

  10.1080/00397911.2010.497594

文献信息

• The phosphazo route to 2-alkenamides from acrylic acid and its derivatives
  作者：José Cabral、Pierre Laszlo、Marie-Thérèse Montaufier、S Lalatiana Randriamahefa

  DOI：10.1016/s0040-4039(00)88859-0

  日期：1990.1

  2-Alkenamides are formed in good isolated yields (generally up to 70%) by the reaction of in situ-generated phosphazo compounds issued from aliphatic, alicyclic and aromatic primary amines, with acrylic acid and its derivatives.

  通过由脂肪族，脂环族和芳香族伯胺发出的原位生成的膦偶氮化合物与丙烯酸及其衍生物的反应，可以形成高分离度的2-烯酰胺（通常最高可达70％）。