[2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetyl] 2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetate | 1596412-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: [2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetyl] 2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetate
• CAS: 1596412-89-3
• 化学式: C₂₂H₂₀N₂O₇
• 分子量: 424.41
• InChiKey: GIDPTVBLAIMBJC-ZBMORAKKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  118
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetyl] 2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetate 、 c,c,t-[Pt(NH₃)2Cl₂(OH)2] 以 二氯甲烷 为溶剂， 反应 336.0h， 以90%的产率得到CisPtXL
  参考文献：
  名称：

  A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin

  摘要：

  The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report the synthesis of polymer nanoparticles (NPs) that carry precise molar ratios of doxorubicin, camptothecin, and cisplatin. To our knowledge, this work provides the first example of orthogonally triggered release of three drugs from single NPs. The highly convergent synthetic approach opens the door to new NP-based combination therapies for cancer.

  DOI：

  10.1021/ja502011g
• 作为产物：
  描述：

  (3,5-dioxo-4-azatricyclo[5.2.1.0^2-exo,6-exo]-dec-8-en-4-yl)ethanoic acid 在 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到[2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetyl] 2-[(1R,2R,6S,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]acetate
  参考文献：
  名称：

  DRUG DELIVERY POLYMER AND USES THEREOF

  摘要：

  本文描述了基于铂的刷状臂星形聚合物（Pt-BASPs），或其药物组合物，用于传递基于铂的药剂，如顺铂。还提供了涉及Pt-BASPs，或其药物组合物，用于治疗增殖性疾病如癌症（例如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、肝癌、肾癌或前列腺癌）的方法和试剂盒。

  公开号：

  US20140308234A1

文献信息

• [EN] DRUG DELIVERY POLYMERS AND USES THEREOF<br/>[FR] POLYMÈRES D'ADMINISTRATION DE MÉDICAMENT ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2017214337A1

  公开（公告）日：2017-12-14

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subj ect.

  本文描述了基于铂的刷臂星形聚合物（Pt-BASPs），或其药物组合物，用于传递基于铂的药物，如奥沙利铂。还提供了涉及Pt-BASPs，或其药物组合物的方法和工具包，用于治疗增殖性疾病，如癌症（例如肺癌，头颈癌，食管癌，胃癌，乳腺癌，胰腺癌，结直肠癌，肝癌，肾癌或前列腺癌）在一个受体中。
• Drug delivery polymer and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10799594B2

  公开（公告）日：2020-10-13

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

  本文描述的是铂基刷臂星型聚合物（Pt-BASPs）或其药物组合物，用于递送铂类制剂，如顺铂。还提供了涉及 Pt-BASPs 或其药物组合物的方法和试剂盒，用于治疗受试者的增殖性疾病，如癌症（如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、肝癌、肾癌或前列腺癌）。
• US9381253B2
  申请人：——

  公开号：US9381253B2

  公开（公告）日：2016-07-05
• [EN] DRUG DELIVERY POLYMER AND USES THEREOF<br/>[FR] POLYMÈRE D'ADMINISTRATION DE MÉDICAMENT ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014169073A1

  公开（公告）日：2014-10-16

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as cisplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.