N-benzyl-1-diethoxyphosphoryl-1-fluoropropan-2-imine | 1265968-76-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: N-benzyl-1-diethoxyphosphoryl-1-fluoropropan-2-imine
• CAS: 1265968-76-0
• 化学式: C₁₄H₂₁FNO₃P
• 分子量: 301.298
• InChiKey: KTOCZJWHIWSOPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  47.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2-氧代-2-苯乙基)膦酸二乙酯 在 Selectfluor 、 苄胺 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 24.0h， 生成 N-benzyl-1-diethoxyphosphoryl-1-fluoropropan-2-imine
  参考文献：
  名称：

  Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor

  摘要：

  A series of alpha-mono- and alpha,alpha-difluoro-beta-ketophosphonates were synthesized in moderate to good yields with excellent selectivities via electrophilic fluorination by Selectfluor. Subsequently, synthetic potential of the obtained alpha-monofluoro-beta-ketophosphonates was demonstrated by their application in synthesis of alpha-monofluoro-beta-aminophosphonates, useful building blocks in the preparation of phosphapeptides.

  DOI：

  10.1021/jo102276y

文献信息

• Selective Synthesis of α-Fluoro-β-keto- and α-Fluoro-β-aminophosphonates via Electrophilic Fluorination by Selectfluor
  作者：Kinga Radwan-Olszewska、Francisco Palacios、Pawel Kafarski

  DOI：10.1021/jo102276y

  日期：2011.2.18

  A series of alpha-mono- and alpha,alpha-difluoro-beta-ketophosphonates were synthesized in moderate to good yields with excellent selectivities via electrophilic fluorination by Selectfluor. Subsequently, synthetic potential of the obtained alpha-monofluoro-beta-ketophosphonates was demonstrated by their application in synthesis of alpha-monofluoro-beta-aminophosphonates, useful building blocks in the preparation of phosphapeptides.