2.3.5.6-Tetrafluor-N-methyl-anilin | 4920-56-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2.3.5.6-Tetrafluor-N-methyl-anilin
• 英文别名: 2,3,5,6-Tetrafluoro-N-methylaniline
• CAS: 4920-56-3
• 化学式: C₇H₅F₄N
• 分子量: 179.117
• InChiKey: SXGZCNWZRSZYMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2.3.5.6-Tetrafluor-N-methyl-anilin 、 碘甲烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 以3.5 g的产率得到2,3,5,6-四氟N,N-二甲基苯胺
  参考文献：
  名称：

  An Aromatic Glaser−Hay Reaction

  摘要：

  A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are reactive. The method is tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.

  DOI：

  10.1021/ja907479j
• 作为产物：
  描述：

  2,3,5,6-四氟苯胺 、 碘甲烷 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.0h， 生成 2.3.5.6-Tetrafluor-N-methyl-anilin
  参考文献：
  名称：

  An Aromatic Glaser−Hay Reaction

  摘要：

  A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are reactive. The method is tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.

  DOI：

  10.1021/ja907479j

文献信息

• IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
  申请人：Bristol-Myers Squibb Company

  公开号：EP3377496B1

  公开（公告）日：2020-09-16
• An Aromatic Glaser−Hay Reaction
  作者：Hien-Quang Do、Olafs Daugulis

  DOI：10.1021/ja907479j

  日期：2009.12.2

  A general method for copper-catalyzed deprotonative dimerization of arenes by employing oxygen as the terminal oxidant has been developed. Electron-rich and electron-poor heterocycles as well as electron-poor arenes are reactive. The method is tolerant to functionalities such as nitro, cyano, dialkylamino, and ester groups.