(Z)-2-(1-methyl-4-nitroimidazol-5-ylmethylene)-3(2H)-benzofuranone | 960064-18-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: (Z)-2-(1-methyl-4-nitroimidazol-5-ylmethylene)-3(2H)-benzofuranone
• 英文别名: (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2H)-benzofuranone；(2Z)-2-[(3-methyl-5-nitroimidazol-4-yl)methylidene]-1-benzofuran-3-one
• CAS: 960064-18-0
• 化学式: C₁₃H₉N₃O₄
• 分子量: 271.232
• InChiKey: UKKAZUGLLLAAAV-WDZFZDKYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  89.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (Z)-2-(1-methyl-4-nitroimidazol-5-ylmethylene)-3(2H)-benzofuranone 在 硫酸 、 硝酸 作用下， 反应 1.0h， 以39%的产率得到(Z)-5-nitro-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2H)-benzofuranone
  参考文献：
  名称：

  Synthesis, antibacterial activity, and quantitative structure–activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3()-benzofuranone derivatives

  摘要：

  A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.062
• 作为产物：
  描述：

  3-苯并呋喃酮 、 (9ci)-1-甲基-4-硝基-1H-咪唑-5-羧醛 在 sodium acetate 作用下， 以 乙酸酐 为溶剂， 以60 %的产率得到(Z)-2-(1-methyl-4-nitroimidazol-5-ylmethylene)-3(2H)-benzofuranone
  参考文献：
  名称：

  (Z)-2-(Nitroimidazolylmethylene)-3(2H)-Benzofuronenes 的抗利什曼活性：NTR 1 和 2 的合成、体外评估和生物激活

  摘要：

  抗菌剂和化疗，印刷前。

  DOI：

  10.1128/aac.00583-22

文献信息

• Synthesis, antibacterial activity, and quantitative structure–activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3()-benzofuranone derivatives
  作者：Narges Hadj-esfandiari、Latifeh Navidpour、Hooman Shadnia、Mohsen Amini、Nasrin Samadi、Mohammad Ali Faramarzi、Abbas Shafiee

  DOI：10.1016/j.bmcl.2007.09.062

  日期：2007.11

  A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities. (C) 2007 Elsevier Ltd. All rights reserved.
• Antileishmanial Activities of ( <i>Z</i> )-2-(Nitroimidazolylmethylene)-3( <i>2H</i> )-Benzofuranones: Synthesis, <i>In Vitro</i> Assessment, and Bioactivation by NTR 1 and 2
  作者：Latifeh Navidpour、Marta Lopes Lima、Rachel Milne、Susan Wyllie、Narges Hadj-esfandiari、Muhammad Iqbal Choudhary、Samreen Khan、Sammer Yousuf

  DOI：10.1128/aac.00583-22

  日期：2022.11.15

  Antimicrobial Agents and Chemotherapy, Ahead of Print.

  抗菌剂和化疗，印刷前。