| 1384472-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1384472-43-8
• 化学式: C₃₇H₄₀N₄O₄
• 分子量: 604.749
• InChiKey: RSCIEKMLSNJOFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.66
• 重原子数：
  45.0
• 可旋转键数：
  11.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  78.26
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  mercuric(II) nitrate monohydrate 、 以 乙醇 、 水 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  A rhodamine based fluorescent probe for Hg2+ and its application to cellular imaging

  摘要：

  A new rhodamine-based fluorescent probe (Rh-F) for detection of Hg2+ ions was synthesized, which could bind Hg2+ in aqueous ethanol (7:3, v/v) at pH 7.0 with detectable change in color and fluorescence. The response is based on a ring opening reaction and formation of a 1:1 complex, while ring-opening process of spirolactam enables large fluorescent enhancement and colorimetric change upon the addition of Hg2+. The response is reversible and linear in the range between 200 nM and 1000 nM, with a detection limit of 4.2 nM. Selectivity and competition experiments with various other metal ion revealed that Rh-F possesses highly selective fluorescent response to Hg2+. Furthermore, the probe was successfully applied to fluorescent imaging of Hg2+ in L-929 cells confirm that Rh-F can be used as a fluorescent probe for monitoring Hg2+ in living cells. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.12.079
• 作为产物：
  描述：

  罗丹明B乙二胺 、 3-furanylacryloyl chloride 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以75%的产率得到
  参考文献：
  名称：

  A rhodamine based fluorescent probe for Hg2+ and its application to cellular imaging

  摘要：

  A new rhodamine-based fluorescent probe (Rh-F) for detection of Hg2+ ions was synthesized, which could bind Hg2+ in aqueous ethanol (7:3, v/v) at pH 7.0 with detectable change in color and fluorescence. The response is based on a ring opening reaction and formation of a 1:1 complex, while ring-opening process of spirolactam enables large fluorescent enhancement and colorimetric change upon the addition of Hg2+. The response is reversible and linear in the range between 200 nM and 1000 nM, with a detection limit of 4.2 nM. Selectivity and competition experiments with various other metal ion revealed that Rh-F possesses highly selective fluorescent response to Hg2+. Furthermore, the probe was successfully applied to fluorescent imaging of Hg2+ in L-929 cells confirm that Rh-F can be used as a fluorescent probe for monitoring Hg2+ in living cells. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2012.12.079