<1,1,4,4-(2)H4>butane-1,4-diamine dihydrochloride | 65372-65-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: <1,1,4,4-(2)H4>butane-1,4-diamine dihydrochloride
• 英文别名: <1,4-2H4>putrescine dihydrochloride；putrescine-[1,1,4,4-d₄]*dihydrochloride
• CAS: 65372-65-8
• 化学式: C₄H₁₂N₂*2ClH
• 分子量: 165.043
• InChiKey: BPHGMWVJJCWDPB-URZLSVTISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.11
• 重原子数：
  7.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.04
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-aminopropyl-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium;hydrogen sulfate;sulfuric acid 、 <1,1,4,4-(2)H4>butane-1,4-diamine dihydrochloride 在 磷酸吡哆醛 、 N-terminally glutathione S-transferase tagged spermidine synthase 、 Cleland's reagent 作用下， 以 aq. phosphate buffer 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  ESI-Q-TOF-MS determination of polyamines and related enzyme activity for elucidating cellular polyamine metabolism

  摘要：

  We developed a new procedure for the comprehensive analysis of metabolites and enzymes involved in polyamine metabolism pathways. The procedure utilizes stable isotope-labeled polyamines and directly and precisely determines labeled products from enzymatic reactions by ESI-Q-TOF-MS. The activity of different enzymes could be determined in essentially the same manner by suitably adjusting the reaction conditions for each individual enzyme. We applied the procedure to extracts of regenerating rat liver and analyzed the changes in polyaminemetabolizing enzymes and polyamine contents during recovery from partial hepatectomy. A general outline of polyamine metabolism and information of polyamine dynamics were obtained. This kind of comprehensive information would be valuable in unifying detailed but fragmentary information obtained through conventional analyses focusing on one or a few enzymes and on a limited aspect of polyamine metabolic pathway.

  DOI：

  10.1016/j.ab.2020.113831