α-(2,4-dichlorobenzyl)-4-methoxybenzyl alcohol | 83580-18-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: α-(2,4-dichlorobenzyl)-4-methoxybenzyl alcohol
• 英文别名: 2-(2,4-Dichlorophenyl)-1-(4-methoxyphenyl)ethanol
• CAS: 83580-18-1
• 化学式: C₁₅H₁₄Cl₂O₂
• 分子量: 297.181
• InChiKey: MBWOYOGNRKUREG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  双(咪唑-1-基)亚砜 、 α-(2,4-dichlorobenzyl)-4-methoxybenzyl alcohol 以 乙腈 为溶剂， 反应 3.5h， 以42%的产率得到1-[2-(2,4-Dichloro-phenyl)-1-(4-methoxy-phenyl)-ethyl]-1H-imidazole
  参考文献：
  名称：

  Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities

  摘要：

  Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.

  DOI：

  10.1016/0223-5234(93)90031-9
• 作为产物：
  描述：

  2,4-二氯苯乙酰氯 在 lithium aluminium tetrahydride 、 三氯化铝 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 α-(2,4-dichlorobenzyl)-4-methoxybenzyl alcohol
  参考文献：
  名称：

  Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities

  摘要：

  Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.

  DOI：

  10.1016/0223-5234(93)90031-9

文献信息

• Anti-microbial diazole derivatives
  申请人：Sankyo Company Limited

  公开号：US04421758A1

  公开（公告）日：1983-12-20

  Compounds of formula (I): ##STR1## [wherein: Q represents a .dbd.CH-- group or a nitrogen atom; R.sup.1 represents a methylene group, a group of formula --CH.sub.2 CH(R.sup.3)--OCH.sub.2 -- (R.sup.3 being a substituted or unsubstituted phenyl group) or a group of formula --(CH.sub.2).sub.n --CH(R.sup.4)--O-- (n being 1 or 2 and R.sup.4 being a substituted or unsubstituted phenyl or phenylalkyl group); and A represents a group of formula --OR.sup.2 (R.sup.2 being an alkenyl group, an alkynyl group or a substituted or unsubstituted alkyl or phenyl group) or a group of formula --CH.sub.2 --XR.sup.11 (X being an oxygen or sulphur atom and R.sup.11 being an aryl or aralkyl group or, when X represents an oxygen atom, R.sup.11 being a hydrogen atom or a carbonyloxy or sulphonyloxy group) and acid addition salts and metal complexes thereof are valuable antimicrobial agents having low toxicity to humans and other animals and are especially valuable for the eradication of fungi.

  化合物的化学式（I）：##STR1##【其中：Q代表.dbd.CH-基团或氮原子；R.sup.1代表亚甲基基团，化学式为--CH.sub.2 CH（R.sup.3）--OCH.sub.2 --（R.sup.3为取代或未取代苯基）或化学式为--（CH.sub.2）.sub.n --CH（R.sup.4）--O--（n为1或2，R.sup.4为取代或未取代苯基或苯基烷基基团）；A代表化学式--OR.sup.2（R.sup.2为烯基基团、炔基基团或取代或未取代烷基或苯基基团）或化学式--CH.sub.2 --XR.sup.11（X为氧原子或硫原子，R.sup.11为芳基或芳基烷基基团或当X代表氧原子时，R.sup.11为氢原子或羰氧基或磺酰氧基团），其酸盐和金属络合物是具有低毒性对人类和其他动物有价值的抗菌剂，特别适用于灭菌真菌。
• Diazole and triazole derivatives, processes for their preparation and anti-microbial compositions containing them
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0055059B1

  公开（公告）日：1985-03-27
• US4421758A
  申请人：——

  公开号：US4421758A

  公开（公告）日：1983-12-20
• Antifungal agents. 5. Chloro and amino derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane with potent antifungal activities
  作者：M Artico、S Massa、R Di Santo、R Costi、A Retico、G Apuzzo、N Simonetti

  DOI：10.1016/0223-5234(93)90031-9

  日期：1993.1

  Various derivatives of 1,2-diaryl-1-(1H-imidazol-1-yl)ethane have been synthesized and tested against Candida albicans and Candida spp. In vitro essays showed chloro and amino derivatives to be as active as miconazole and bifonazole and more potent than ketoconazole. Structure-activity relationships of the new imidazole antifungal agents are discussed.