1-butyl-3-[(Z)-thiophen-2-ylmethylideneamino]thiourea

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-butyl-3-[(Z)-thiophen-2-ylmethylideneamino]thiourea
• 化学式: C₁₀H₁₅N₃S₂
• 分子量: 241.381
• InChiKey: OEYWNCWBCKBUOM-WQLSENKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  96.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丁基硫代氨基甲酸 在 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 生成 1-butyl-3-[(Z)-thiophen-2-ylmethylideneamino]thiourea
  参考文献：
  名称：

  Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica

  摘要：

  In an effort to develop potent antiamoebic agents, a series of thiosemicarbazone (TSC) ligands 1-5 derived from thiophene-2carboxaldehyde and N-4-substituted thiosemicarbazides has been prepared and characterized using various spectroscopic techniques. Treatment of the ligands with cupric chloride produced the copper(H) complexes [Cu(TSC)(2)Cl-2] 1a-5a where ligand bind through thionic sulfur and the azomethine nitrogen. The possible geometries of the complexes were assigned on the basis of magnetic moment, electronic and thermal patterns as well as infrared spectral studies. The thiosemicarbazones and their copper complexes were tested for their in vitro antiamoebic activity against HK-9 strain of Entamoeba histolytica and showed significant growth inhibition. The results revealed that these complexes are effective chemicals in inhibiting amoebal growth, with compound 5 (having -N(CH3)(C6H5) substituent at N-4) and complexes 1a-5a being more effective than the commercial antiamoebic drug, metronidazole, based on IC50 values. These data also indicated that the compounds 3a and 5a are most effective among the complexes studied (IC50 = 0.26 mu M of 3a and IC50 = 0.21 mu M of 5a versus IC50 = 1.81 mu M of metronidazole). (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.05.013

文献信息

• Copper(II) complexes with substituted thiosemicarbazones of thiophene-2-carboxaldehyde: synthesis, characterization and antiamoebic activity against E. histolytica
  作者：Sangita Sharma、Fareeda Athar、Mannar R. Maurya、Amir Azam

  DOI：10.1016/j.ejmech.2005.05.013

  日期：2005.12

  In an effort to develop potent antiamoebic agents, a series of thiosemicarbazone (TSC) ligands 1-5 derived from thiophene-2carboxaldehyde and N-4-substituted thiosemicarbazides has been prepared and characterized using various spectroscopic techniques. Treatment of the ligands with cupric chloride produced the copper(H) complexes [Cu(TSC)(2)Cl-2] 1a-5a where ligand bind through thionic sulfur and the azomethine nitrogen. The possible geometries of the complexes were assigned on the basis of magnetic moment, electronic and thermal patterns as well as infrared spectral studies. The thiosemicarbazones and their copper complexes were tested for their in vitro antiamoebic activity against HK-9 strain of Entamoeba histolytica and showed significant growth inhibition. The results revealed that these complexes are effective chemicals in inhibiting amoebal growth, with compound 5 (having -N(CH3)(C6H5) substituent at N-4) and complexes 1a-5a being more effective than the commercial antiamoebic drug, metronidazole, based on IC50 values. These data also indicated that the compounds 3a and 5a are most effective among the complexes studied (IC50 = 0.26 mu M of 3a and IC50 = 0.21 mu M of 5a versus IC50 = 1.81 mu M of metronidazole). (c) 2005 Elsevier SAS. All rights reserved.