4-(4-Benzylsulfonylpiperazin-1-yl)-3-(4-fluorophenyl)-1-phenyl-pyridin-2-one | 1062059-11-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(4-Benzylsulfonylpiperazin-1-yl)-3-(4-fluorophenyl)-1-phenyl-pyridin-2-one
• 英文别名: 4-(4-benzylsulfonylpiperazin-1-yl)-3-(4-fluorophenyl)-1-phenylpyridin-2-one
• CAS: 1062059-11-3
• 化学式: C₂₈H₂₆FN₃O₃S
• 分子量: 503.597
• InChiKey: LJTCPSBIRXCOOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  69.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-oxo-1,2-dihydropyridin-4-yl trifluoromethanesulfonate 在 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 copper diacetate 、 三乙胺 、 lithium chloride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 133.0h， 生成 4-(4-Benzylsulfonylpiperazin-1-yl)-3-(4-fluorophenyl)-1-phenyl-pyridin-2-one
  参考文献：
  名称：

  SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

  摘要：

  A novel series of pyridazinone analogs has been developed as potent beta-1,3-glucan synthase inhibitors through structure-activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one (1). The effect of changes to the core structure is described in detail. Optimization of the sulfonamide moiety led to the identification of important compounds with much improved systematic exposure while retaining good antifungal activity against the fungal strains Candida glabrata and Candida albicans. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2011.03.083

文献信息

• Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors
  申请人：Ting Pauline C.

  公开号：US20090170861A1

  公开（公告）日：2009-07-02

  In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

  在其多种实施方式中，本发明提供了取代的吡啶嗪酮化合物作为葡聚糖合成酶抑制剂，制备这种化合物的方法，包括一种或多种这种化合物的制药物，制备包括一种或多种这种化合物或一种或多种这种化合物与其他抗真菌药物共同使用的制药配方的方法，以及使用这种化合物或制药组合物治疗、预防、抑制或改善与葡聚糖合成酶相关的一种或多种真菌感染的方法。
• Pyridazinone derivatives useful as glucan synthase inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2586778A2

  公开（公告）日：2013-05-01

  In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

  在其许多实施方案中，本发明提供了作为葡聚糖合成酶抑制剂的-取代哒嗪酮化合物、制备此类化合物的方法、包括一种或多种此类化合物的药物、制备包括一种或多种此类化合物或一种或多种此类化合物与其他抗真菌剂的药物制剂的方法，以及使用此类化合物或药物组合物治疗、预防、抑制或改善与葡聚糖合成酶相关的一种或多种真菌感染的方法。
• US8232274B2
  申请人：——

  公开号：US8232274B2

  公开（公告）日：2012-07-31
• [EN] PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'INHIBITEURS DE SYNTHASE DE GLUCANE
  申请人：SCHERING CORP

  公开号：WO2008115381A1

  公开（公告）日：2008-09-25

  [EN] In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.
  [FR] L'invention concerne des composés de pyridazinone substitués en tant qu'inhibiteurs de synthase de glucane ; des procédés de préparation de tels composés, des produits pharmaceutiques comprenant un ou plusieurs de ces composés ; des procédés de préparation de formulations pharmaceutiques comprenant un ou plusieurs de ces composés seuls ou avec d'autres agents antifongiques ; et des procédés de traitement, de prévention, d'inhibition, ou d'amélioration d'une ou de plusieurs infections fongiques associées à une synthase de glucane utilisant de tels composés ou compositions pharmaceutiques.
• SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors
  作者：Gang Zhou、Pauline C. Ting、Robert Aslanian、Jianhua Cao、David W. Kim、Rongze Kuang、Joe F. Lee、John Schwerdt、Heping Wu、R. Jason Herr、Andrew J. Zych、Jinhai Yang、Sang Lam、Samuel Wainhaus、Todd A. Black、Paul M. McNicholas、Yiming Xu、Scott S. Walker

  DOI：10.1016/j.bmcl.2011.03.083

  日期：2011.5

  A novel series of pyridazinone analogs has been developed as potent beta-1,3-glucan synthase inhibitors through structure-activity relationship study of the lead 5-[4-(benzylsulfonyl)piperazin-1-yl]-4-morpholino-2-phenyl-pyridazin-3(2H)-one (1). The effect of changes to the core structure is described in detail. Optimization of the sulfonamide moiety led to the identification of important compounds with much improved systematic exposure while retaining good antifungal activity against the fungal strains Candida glabrata and Candida albicans. Published by Elsevier Ltd.