methyl (Z)-2-ethoxy-3-(4-methoxyphenyl)acrylate | 1333382-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl (Z)-2-ethoxy-3-(4-methoxyphenyl)acrylate
• 英文别名: methyl (Z)-2-ethoxy-3-(4-methoxyphenyl)prop-2-enoate
• CAS: 1333382-78-7
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: VGIMYTKYNSHCFI-XFXZXTDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲醇 、 2-Ethoxy-3-(4-methoxyphenyl)prop-2-enoic acid 在 硫酸 作用下， 反应 6.0h， 以94%的产率得到methyl (Z)-2-ethoxy-3-(4-methoxyphenyl)acrylate
  参考文献：
  名称：

  Biotechnological Development of a Practical Synthesis of Ethyl (S)-2-Ethoxy-3-(p-methoxyphenyl)propanoate (EEHP): Over 100-Fold Productivity Increase from Yeast Whole Cells to Recombinant Isolated Enzymes

  摘要：

  The coupling of the enantioselective reduction catalyzed by Old Yellow Enzymes (OYEs), together with the in situ substrate feeding product removal (SFPR) concept, significantly improved the productivity of the g-scale preparation of ethyl (S)-2ethoxy-3-(p-methoxyphenyl)propanoate (EEHP), an important precursor of several PPAR-alpha/gamma agonists, such as Tesaglitazar. The OYEs and the glucose dehydrogenase for cofactor regeneration were cloned, overexpressed in Escherichia coli, and purified. The synthetic sequence was completed by a NaClO2 oxidation employing cheap and environmentally friendly conditions. The product was obtained in 94% yield and with an ee of 98% over the two steps.

  DOI：

  10.1021/op200085k

文献信息

• Organic polymeric materials stabilized with calcium stearoyl lactate
  申请人：K.K. Musashino Kagaku Kenkyusho

  公开号：EP0029803A2

  公开（公告）日：1981-06-03

  Organic polymers selected from the group consisting of - polyolefins unsaturated elastomers - copolymers of monoolefines and diolefines with other vinyl monomers - polystyrene and copolymers thereof - polymers which are derived from α,β-unsaturated acids and derivatives thereof and copolymers of these monomers with other unsaturated monomers - polymers derived from unsaturated alcohols and amines or derivatives thereof - polyacetals - polamides and copolyamides are stabilized against thermooxidative deterioration by the addition of acylated hydroxy acid type compounds of the formula (I) Reference is made to claim 1 with regard to the meanings of the substituents and symbols in formula (1).

  不饱和弹性体聚烯烃--单烯烃和二烯烃与其他乙烯基单体的共聚物--聚苯乙烯及其共聚物--由 α，β-不饱和酸及其衍生物衍生的聚合物以及这些单体与其他不饱和单体的共聚物--由不饱和醇和胺或其衍生物衍生的聚合物--聚缩醛--多酰胺和共聚多酰胺 通过添加式（I）的酰化羟基酸类化合物，可防止热氧化变质。 关于式（1）中取代基和符号的含义，请参阅权利要求 1。
• US4366280A
  申请人：——

  公开号：US4366280A

  公开（公告）日：1982-12-28