N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide | 173668-78-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide
• 英文别名: N-[2-(3H-benzo[f]chromen-10-yl)ethyl]acetamide
• CAS: 173668-78-5
• 化学式: C₁₇H₁₇NO₂
• 分子量: 267.327
• InChiKey: FTZVUKIJZSOGMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide 在 镍 氢气 作用下， 以 乙醇 为溶剂， 以55%的产率得到N-[2-(2,3,7,8,9,10-Hexahydro-1H-benzo[f]chromen-10-yl)-ethyl]-acetamide
  参考文献：
  名称：

  Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin

  摘要：

  A serie of rotationally restricted tricyclic naphthalenic and tetrahydronaphthalenic analogs of the hormone melatonin has been synthesized, the C-7 oxygen being incorporated in a pyran, furan or dioxan heterocyclic ring. The receptor binding profile of these compounds is a function of the directionality of the lone pairs electrons of this C-7 oxygen. In these two studied analogous series the agonist activity seems to be correlated with the existence of a naphthalene nucleus. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00175-8
• 作为产物：
  描述：

  N-(2-(7-羟基萘-1-基)乙基)乙酰胺 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 N-[2-(3H-Benzo[f]chromen-10-yl)-ethyl]-acetamide
  参考文献：
  名称：

  Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin

  摘要：

  A serie of rotationally restricted tricyclic naphthalenic and tetrahydronaphthalenic analogs of the hormone melatonin has been synthesized, the C-7 oxygen being incorporated in a pyran, furan or dioxan heterocyclic ring. The receptor binding profile of these compounds is a function of the directionality of the lone pairs electrons of this C-7 oxygen. In these two studied analogous series the agonist activity seems to be correlated with the existence of a naphthalene nucleus. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00175-8

文献信息

• NAPHTHALENE DERIVATIVES, METHOD OF PREPARATION AND USE
  申请人：GLAXO GROUP LIMITED

  公开号：EP0821681A1

  公开（公告）日：1998-02-04
• JPH10502336A
  申请人：——

  公开号：JPH10502336A

  公开（公告）日：1998-03-03
• [EN] NAPHTHALENE DERIVATIVES, METHOD OF PREPARATION AND USE<br/>[FR] DERIVES NAPHTALENE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION
  申请人：GLAXO GROUP LIMITED

  公开号：WO1995029173A1

  公开（公告）日：1995-11-02

  (EN) A compound of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1 is a group of the formula -CR3R4(CH2)pNR5COR6; R2 is hydrogen, halogen, C1-6alkyl, OR7 or CO2R7, and may be the same or different substituent when q is 2; R3, R4 and R5, which may be the same or different, are hydrogen or C1-6alkyl; R6 is C1-6alkyl or C3-7cycloalkyl; R7 is hydrogen or C1-6alkyl; n is zero, 1 or 2; p is an integer of 1, 2, 3 or 4; q is 1 or 2; and the dotted lines indicate the absence or presence of an additional bond.(FR) Composé de la formule (I) ainsi que ses sels et solvates acceptables sur le plan pharmacologique. Dans cette formule, R1 représente un groupe de la formule -CR3R4(CH2)pNR5COR6; R2 représente hydrogène, halogène, alcoyle C1-6, OR7 ou CO2R7 et il peut être le même substituant ou un substituant différent, lorsque q vaut 2; R3, R4 et R5, qui peuvent être semblables ou différents, représentent hydrogène ou alcoyle C1-6; R6 représente alcoyle C1-6 ou cycloalcoyle C3-7; R7 représente hydrogène ou alcoyle C1-6; n vaut zéro, 1 ou 2; p est un nombre entier valant 1, 2, 3 ou 4; q vaut 1 ou 2; et les lignes en pointillé indiquent l'absence ou la présence d'une liaison supplémentaire.
• Synthesis and biological activity of conformationally restricted tricyclic analogs of the hormone melatonin
  作者：V. Leclerc、P. Depreux、D. Lesieur、D.H. Caignard、P. Renard、P. Delagrange、B. Guardiola-Lemaitre、P. Morgan

  DOI：10.1016/0960-894x(96)00175-8

  日期：1996.5

  A serie of rotationally restricted tricyclic naphthalenic and tetrahydronaphthalenic analogs of the hormone melatonin has been synthesized, the C-7 oxygen being incorporated in a pyran, furan or dioxan heterocyclic ring. The receptor binding profile of these compounds is a function of the directionality of the lone pairs electrons of this C-7 oxygen. In these two studied analogous series the agonist activity seems to be correlated with the existence of a naphthalene nucleus. (C) 1996 Elsevier Science Ltd